1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors

Autor:	Qinghua Weng, Andrew P. Crew, Kathryn M. Stolz, Izabela Sujka, Qun-Sheng Ji, Lydia Saroglou, Robin Wilkes, Patricia Beck, Cara Cesario, Andrew Cooke, Mark J. Mulvihill, K.W. Foreman, Brian Volk, Anthony Nigro, Matthew Cox, Gilda Mak, Doug Werner, Matthew O'Connor, Hanqing Dong, Lixin Feng
Rok vydání:	2006
Předmět:	Models Molecular Stereochemistry Clinical Biochemistry Pharmaceutical Science Biological Availability Crystallography X-Ray Biochemistry Chemical synthesis Receptor IGF Type 1 Mice Structure-Activity Relationship Adenosine Triphosphate Growth factor receptor Drug Discovery Animals Databases Protein Molecular Biology Insulin-like growth factor 1 receptor chemistry.chemical_classification Binding Sites biology Bicyclic molecule Chemistry Organic Chemistry Imidazoles Protein-Tyrosine Kinases Insulin receptor Enzyme Enzyme inhibitor Area Under Curve Pyrazines biology.protein Molecular Medicine Indicators and Reagents Signal transduction Half-Life
Zdroj:	Bioorganicmedicinal chemistry letters. 17(4)
ISSN:	0960-894X
Popis:	A series of novel 8-amino-1,3-disubstituted-imidazo[1,5-a]pyrazines was designed and synthesized as IGF-IR inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029cf74ac11b81e0a031f3b2ae2e79cb https://pubmed.ncbi.nlm.nih.gov/17127062 Zobrazit plný text záznamu Full Text from ScienceDirect