The retrospective analysis of 343 Czech patients with IgA nephropathy--one centre experience
| Autor: | Eva Honsova, Romana Rysava, Jelena Skibova, Miroslav Merta, Dita Maixnerova, Lenka Bauerová, Vladimir Tesar, Jana Reiterova |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Nephrology medicine.medical_specialty Azathioprine macromolecular substances Gastroenterology Nephropathy chemistry.chemical_compound Risk Factors Internal medicine otorhinolaryngologic diseases medicine Humans Aged Czech Republic Retrospective Studies Aged 80 and over Transplantation Univariate analysis Creatinine Proteinuria medicine.diagnostic_test business.industry Glomerulonephritis IGA Odds ratio Middle Aged Prognosis medicine.disease Survival Rate carbohydrates (lipids) stomatognathic diseases Endocrinology chemistry Hypertension Multivariate Analysis Kidney Failure Chronic bacteria Female Renal biopsy medicine.symptom business Follow-Up Studies Glomerular Filtration Rate medicine.drug |
| Zdroj: | Nephrology Dialysis Transplantation. 27:1492-1498 |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/gfr482 |
| Popis: | The aim of our study was to retrospectively analyse the clinical data and the histological findings of 343 patients (pts) followed up with IgA nephropathy (IgAN) in our department of nephrology. We have assessed the main demographic, clinical and histological data, and the medical treatment of IgAN pts.Multivariate analysis was used to evaluate the effect of different variables on ≥50% increase of plasma creatinine level from baseline during a median follow-up of 4 years.In our group of IgAN pts, the male gender (68%) predominated over female gender (32%). At the time of renal biopsy, the median age of IgAN pts was 32.3 (18-90) years, the median level of serum creatinine was 119 μmol/L and the median level of proteinuria was 1.8 g/day. Most of the pts were found to have arterial hypertension (56.7%). The majority of the pts with arterial hypertension were treated with inhibitors of angiotensin-converting enzyme (80.4%) and the remaining pts (42.6%) were treated with angiotensin II receptor blockers. Fifty per cent of the pts (170 pts) were treated of corticosteroids, 21% of the pts (71 pts) used a combined immunosuppressive treatment of corticosteroids and cyclophosphamide, 8% of the pts (27 pts) took azathioprine, 1.5% of the pts (5 pts) took cyclosporine and 1.5% of the pts (5 pts) were given mycophenolate mofetil. Hypertension at presentation, fibrointimal proliferation of arterial vessels, interstitial fibrosis and interstitial inflammation were shown to be associated with ≥50% increase of plasma creatinine level from baseline in univariate analysis (P0.05 for hypertension and fibrointimal proliferation; P0.01 for interstitial fibrosis and inflammation). Using stepwise logistic regression presenting proteinuria2 g/day [odds ratio (OR)=2.24, P0.01], tubular atrophy (OR=4.97, P0.01) and damage of tubular epithelium (OR=1.78, P0.05) were found as risk factors for ≥50% increase of plasma creatinine level from baseline.Our retrospective analysis found valuable information not only about the clinical, laboratory and histological findings in IgAN pts but also information about the risk factors influencing the progression of renal insufficiency. |
| Databáze: | OpenAIRE |
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