Evaluation of healthcare utilization and health status of patients with Parkinson's disease treated with deep brain stimulation of the subthalamic nucleus

Autor: Wolfgang H. Oertel, Delia Lorenz, Karin Berger, Richard Dodel, Volker Sturm, Paul Krack, D. Hellwig, E. A. Spottke, A Smala, H.-J. Freund, A. Gerstner, Jens Volkmann, Günther Deuschl
Jazyk: angličtina
Rok vydání: 2002
Předmět:
Male
medicine.medical_specialty
Parkinson Disease/drug therapy/physiopathology/*surgery
Deep brain stimulation
Parkinson's disease
Neurology
Cost effectiveness
Health Care Costs/*statistics & numerical data
Cost-Benefit Analysis
Health Status
medicine.medical_treatment
Electric Stimulation Therapy/economics/*statistics & numerical data
Electric Stimulation Therapy
Disease
Drug Costs
Antiparkinson Agents
Central nervous system disease
Delivery of Health Care/*utilization
Degenerative disease
Subthalamic Nucleus
Internal medicine
Germany
medicine
Humans
Aged
business.industry
Drug Costs/statistics & numerical data
Cost-Benefit Analysis/statistics & numerical data
Parkinson Disease
Health Care Costs
Middle Aged
medicine.disease
Antiparkinson Agents/administration & dosage/adverse effects/*economics
nervous system diseases
Subthalamic nucleus
surgical procedures
operative
nervous system
Subthalamic Nucleus/physiology/*surgery
Physical therapy
Female
Neurology (clinical)
business
Delivery of Health Care
therapeutics
Zdroj: Journal of Neurology, Vol. 249, No 6 (2002) pp. 759-766
ISSN: 0340-5354
Popis: To assess the effects on motor functioning, health status and direct medical costs of high-frequency stimulation of the subthalamic nucleus (DBS-STN) in patients with idiopathic Parkinson's disease (PD). In addition, the cost-effectiveness of DBS-STN vs. drug treatment was investigated.16 consecutive patients with PD from two centers (Düsseldorf/Cologne; Kiel) treated by DBS-STN were prospectively evaluated. Clinical evaluations were done at baseline and 1, 3, 6, 12 months following surgery by means of the Unified Parkinson's disease Rating Scale (UPDRS). Health status of PD patients was assessed using the Sickness Impact Profile (SIP) at baseline and 6 months following surgery. Relevant economic data were taken from the medical records and costs (1999) were derived from different German medical economic resources. Costs were determined from the perspective of the health care provider.Following DBS-STN UPDRS scores (subscores and sum score) as well as health status improved considerably in PD patients. The overall SIP score and the physical dimension score (p0.009) were significantly different (p0.01) six month after surgery compared with baseline values. Mean costs of DM 40,020 (US dollars 20,810, EURO 20,410, GB pounds 12,810) per patient were spent during the 12 month observation period for in-patient and out-patient care. These expenses included already the costs for the electronic device for bilateral stimulation. Following DBS-STN medication was considerably reduced. Mean daily drug costs at baseline were DM 46.7+/-21.8 (US dollars 24, EURO 24, GB pounds 15) and DM 18.3+/-17.7 (US dollars 10, EURO 9, GB pounds 6) at 12 months following DBS-STN. Accounting for the decreased drug consumption, total annual costs amounted to DM 31,400 (US dollars 16,330, EURO 16,010, GB pounds 10,050). Further, we estimated the incremental cost effectiveness as DBS-STN had higher costs but was more effective than baseline treatment. The incremental total cost-effectiveness ratio for DBS-STN was DM 1.800 (US dollars 940, EURO 920, GB pounds 580) for one point decrease of the UPDRS.DBS-STN is an effective treatment that considerably alleviates the severity of signs and symptoms and improves the health status of patients with PD. Compared with drug treatment, however, the expenditures associated with DBS-STN are increased when only direct medical costs are considered in a one year horizon. However, on a long-term basis costs will decrease considerably because of the reduction of the drug expenditure and improved functioning in all activities of daily living. To adequately evaluate the cost-effectiveness of DBS-STN compared with standard drug regimen for PD it is necessary to include direct, indirect and intangible costs on a long-term basis and under standardized circumstances.
Databáze: OpenAIRE
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