Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study
| Autor: | F Lisi, Donatella Caserta, Valeria Raparelli, E. Vaquero, Rosella Lisi, R. Poverini, Claudio Manna, Massimo Moscarini, Piero Carfagna, Roberto Marci, Rocco Rago, Mario Montanino Oliva |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
myo-inositol
inositol follicle stimulation IVF ICSI oocytes embryos Infertility Follicle Adult medicine.medical_specialty lcsh:QH471-489 Pregnancy Rate medicine.medical_treatment Stimulation Pilot Projects Fertilization in Vitro Biology lcsh:Gynecology and obstetrics Intracytoplasmic sperm injection Andrology Endocrinology Folic Acid Pregnancy Internal medicine Follicular phase medicine lcsh:Reproduction Settore MED/05 - Patologia Clinica Humans Sperm Injections Intracytoplasmic lcsh:RG1-991 In vitro fertilisation Research Embryos Inositol Myo-inositol Oocytes Obstetrics and Gynecology medicine.disease Polycystic ovary Pregnancy rate Reproductive Medicine Settore MED/40 - Ginecologia e Ostetricia Female icsi ivf Infertility Female Developmental Biology |
| Zdroj: | Reproductive Biology and Endocrinology : RB&E Reproductive Biology and Endocrinology, Vol 10, Iss 1, p 52 (2012) |
| ISSN: | 1477-7827 |
| Popis: | Background Aim of this pilot study is to examine the effects of myo-inositol administration on ovarian response and oocytes and embryos quality in non PolyCystic Ovary Syndrome (PCOS) patients undergoing multiple follicular stimulation and in vitro insemination by conventional in vitro fertilization or by intracytoplasmic sperm injection. Methods One hundred non-PCOS women aged Results Total length of the stimulation was similar between the two groups. Nevertheless, total amount of gonadotropins used to reach follicular maturation was found significantly lower in group B. In addition, the number of oocytes retrieved was significantly reduced in the group pretreated with myo-inositol. Clinical pregnancy and implantation rate were not significantly different in the two groups. Conclusions Our findings suggest that the addition of myo-inositol to folic acid in non PCOS-patients undergoing multiple follicular stimulation for in-vitro fertilization may reduce the numbers of mature oocytes and the dosage of rFSH whilst maintaining clinical pregnancy rate. Further, a trend in favor of increased incidence of implantation in the group pretreated with myo-inositol was apparent in this study. Further investigations are warranted to clarify this pharmacological approach, and the benefit it may hold for patients. |
| Databáze: | OpenAIRE |
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