Investigating the epigenetic profile of the inflammatory gene IL-6 in late-life depression

Autor: Katharina Neuhaus, Richard Saffery, Karen Ritchie, Marie-Laure Ancelin, Lauren Pilkington, Joanne Ryan
Přispěvatelé: Department of Epidemiology and Preventive Medicine [Melbourne, VIC, Australia], Monash University [Clayton], Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Cancer & Disease Epigenetics [Parkville, VIC, Australia], University of Melbourne-Royal Children’s Hospital & Department of Paediatrics [Parkville, VIC, Australia]-Murdoch Children's Research Institute (MCRI), The ESPRIT project is financed by the regional government of Languedoc- Roussillon, the Agence Nationale de la Recherche (ANR) Project 07 LVIE 004, and an unconditional grant from Novartis. RS is funded by an NHMRC Senior Research Fellowship and the Victorian Government (Australia) Operational Infrastructure Support Scheme., ANR-07-LVIE-0004,ESPRIT-VIE,Interaction entre la vulnérabilité génétique, la dysrégulation biologique et le stress dans la dépression du sujet âgé(2007), BMC, BMC, Longévité et vieillissement - Interaction entre la vulnérabilité génétique, la dysrégulation biologique et le stress dans la dépression du sujet âgé - - ESPRIT-VIE2007 - ANR-07-LVIE-0004 - LVIE - VALID, University of Melbourne-Murdoch Children's Research Institute (MCRI)-Royal Children’s Hospital & Department of Paediatrics [Parkville, VIC, Australia], Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Rok vydání: 2017
Předmět:
Zdroj: BMC Psychiatry, Vol 17, Iss 1, Pp 1-7 (2017)
BMC Psychiatry
BMC Psychiatry, BioMed Central, 2017, 17 (1), pp.354. ⟨10.1186/s12888-017-1515-8⟩
ISSN: 1471-244X
Popis: International audience; BackgroundIt is well established that there is a link between inflammation and depression, with several studies reporting increased circulating levels of the pro-inflammatory cytokine, interleukin-6 (IL6), in depressed individuals. Peripheral epigenetic marks, including DNA methylation, hold promise as biomarkers for a range of complex conditions, with potential to inform diagnosis and tailor interventions. The aim of this study was to determine whether individuals with depression display differential methylation of the IL6 gene promoter compared to individuals without depression.MethodsThe ESPRIT study of later life neuropsychiatric disorders used a random sampling framework to select non-institutionalised participants aged ≥65 years and over living in the Montpellier region of France. Major depressive disorder (MDD) was assessed using the Mini International Neuropsychiatric Interview (MINI) according to DSM-IV criteria. High levels of depressive symptoms were defined as a score of ≥16 on the Centre for Epidemiologic Studies Depression Scale (CES-D). IL6 promoter DNA methylation was measured on a sub-sample of 380 participants who provided buccal samples.ResultsIndividuals with depression (current MDD or high depressive symptoms) had lower IL6 methylation levels at one of the four sites investigated, however the effect size was small (∆ 2.4%, SE 0.009, p = 0.006). Interestingly, antidepressant use was independently associated with higher IL-6 methylation at the same site (∆ 4.6%, SE 0.019, p = 0.015). In multivariate linear regression analyses adjusting for covariates, including sex and smoking status, these associations remained. There was no effect modification when considering IL6 genotype.ConclusionThis study presents evidence that IL6 methylation may be a marker of depression status in older individuals, however further work is now needed to replicate these findings and to assess the association with inflammatory status of individuals.
Databáze: OpenAIRE
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