Surgical analysis of pediatric and adolescent sporadic pheochromocytoma: single center experience
| Autor: | Yasser Osman, Ahmed A. Shorrab, Osama Sarhan, Mohamed A. Ghoneim, Naser Hussein, Mohamed Dawaba |
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| Rok vydání: | 2011 |
| Předmět: |
Nephrology
Male medicine.medical_specialty Pediatrics endocrine system diseases Adolescent Urology Adrenal Gland Neoplasms Pheochromocytoma Anesthesia General Malignancy Single Center Internal medicine medicine Humans Neoplasm Metastasis Child Retrospective Studies Surgical approach business.industry Incidence (epidemiology) Follow up studies Retrospective cohort study medicine.disease Surgery Radiography Child Preschool Female Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | International urology and nephrology. 43(4) |
| ISSN: | 1573-2584 |
| Popis: | The aim of this study is to review our experience with sporadic pheochromocytoma in pediatrics and adolescents focusing upon surgical approach, incidence of malignancy, and recurrence rate.Between 1990 and 2007, 8 pediatric patients were diagnosed with sporadic pheochromocytoma. Demographic data, clinical and radiological findings, laboratory profile, preoperative preparation, surgical approach, operative findings, postoperative course as well as pathologic diagnosis of the removed specimen were reviewed.Mean age of presentation was 13.1 ± 4.7 years. Five patients had right-sided masses, 1 harbored left-sided mass, and bilaterality was observed in 2 with mean size of 5.7 ± 1.3 cm. Computed tomography showed no evidence of local infiltration, regional lymphadenopathy or distant metastasis in all patients but two. Six masses were excised through thoraco-abdominal approach, 3 were removed laparoscopically, while percutaneous alcohol ablation was adopted for the last. We had one postoperative death (12.5%:1/8), and the remaining 7 patients were followed for a mean of 8.6 ± 3 years. Five patients never had recurrence. Bilateral recurrence developed in 2 patients, where they were safely excised in one patient and was a part of disseminated disease in the other. Malignant nature of the disease was proved in 2 patients and showed poor survival.Under adequate anesthetic control, pediatric pheochromocytoma could be safely managed through both the open and laparoscopic approaches. Advanced radiological stage would suggest the malignant nature of the disease with dismal outcome. Long-term follow-up is warranted for possibility of delayed curable recurrence. |
| Databáze: | OpenAIRE |
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