Need for pharmacogenetic studies on the prevalence of MTHFR mutations in Puerto Ricans and Hispanics
| Autor: | Raúl H Morales-Borges |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Genotype Population Pharmacology toxicology 030105 genetics & heredity Pharmacogenetic Study 03 medical and health sciences Genotype-phenotype distinction Prevalence Medicine Humans Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics education Methylenetetrahydrofolate Reductase (NADPH2) education.field_of_study Retrospective review biology business.industry Puerto Rico Hispanic or Latino digestive system diseases 030104 developmental biology Cross-Sectional Studies Phenotype Pharmacogenetics Research Design Methylenetetrahydrofolate reductase Mutation biology.protein business Demography |
| Zdroj: | Drug metabolism and personalized therapy. 32(3) |
| ISSN: | 2363-8915 |
| Popis: | Methylenetetrahydrofolate reductase (MTHFR) mutations have been linked to many diseases. Evidence has been provided to prove that we need to perform pharmacogenetic studies regarding the prevalence of MTHFR mutations and diseases, risks, and the impact on folate requirement in general, but little has been published about Puerto Ricans. A multi center cross-sectional retrospective review study or a prospective pharmacogenetic study of valid genotypes and phenotypes of MTHFR mutations within the different populations of Puerto Ricans and Hispanics are recommended, because differences within them and within the general population are expected. |
| Databáze: | OpenAIRE |
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