| Popis: |
Aim of the present study was to evaluate the antidepressant activity of Hibiscus rosa sinensis in experimental models of depression using mice. To study the effect of Hibiscus rosa sinensis on behavior models of depression like forced swim test, tail suspension test. To study the effect of Hibiscus rosa sinensis on mechanism based models of depression like 5-HTP induced head twitches, clonidine induced aggression and L-Dopa induced hyperactivity and aggressive behavior. To study the effect of Hibiscus rosa sinensis on anti-oxidant levels of brain. The results from the present study confirm the antidepressant activity of hibiscus rosa sinensis, since it reduced the immobility in both FST and TST. In the present study, hibiscus rosa sinensis significantly increased the frequency of 5-HTP induced head twitches, Clonidine induced aggression and L-DOPA induced hyperactivity and aggressive behavior indicating its enhanced activity on serotonergic, noradrenergic and dopaminergic pathways respectively. Our results also confirm the involvement of serotonergic, noradrenergic and dopaminergic pathways in depression. Pretreatment with hibiscus rosa sinensis, also significantly increased the levels of SOD and Catalase with simultaneous decrease in LPO levels in mice brain, suggesting its strong antioxidant activity. Since oxidative stress is reported to play an important role in depression, the antioxidant activity of hibiscus rosa sinensis might be a part of the mechanism for its antidepressant activity. Results from behavioral experiments indicate that the antidepressant activity of hibiscus rosa sinensis, might be due to the facilitatory effect on serotonergic, noradrenergic and dopaminergic systems apart from the antioxidant activity. Keywords: Depression, Hibiscus rosa sinensis etc.,. |
