Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

Autor: Connor A. Emdin, Mark J. Daly, Aki S. Havulinna, Aitzkoa Lopez de Lapuente Portilla, Saiju Pyarajan, Christopher P. Nelson, Pradeep Natarajan, Bo Li, Tuomo Kiiskinen, Benjamin M. Neale, Aviv Regev, John E. Dick, Christopher J. Walker, Marcin Tabaka, Xiaotian Liao, Juha Karjalainen, Aarno Palotie, Claire Churchhouse, Christopher J. O'Donnell, Daryl E. Klein, Peter W.F. Wilson, Michael Milyavsky, Vijay G. Sankaran, Albert de la Chapelle, Olga I. Gan, Caleb A. Lareau, Alexander G. Bick, Björn Nilsson, Erik L. Bao, Nilesh J. Samani, Satish K. Nandakumar, Veryan Codd, J. Michael Gaziano, Sekar Kathiresan, Kelly Cho
Rok vydání: 2019
Předmět:
Zdroj: Nature
ISSN: 1476-4687
Popis: Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the excessive production of mature myeloid cells and arise from the acquisition of somatic driver mutations in haematopoietic stem cells (HSCs). Epidemiological studies indicate a substantial heritable component of MPNs that is among the highest known for cancers1. However, only a limited number of genetic risk loci have been identified, and the underlying biological mechanisms that lead to the acquisition of MPNs remain unclear. Here, by conducting a large-scale genome-wide association study (3,797 cases and 1,152,977 controls), we identify 17 MPN risk loci (P
Databáze: OpenAIRE
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