Investigating the effect of supramolecular gel phase crystallization on gel nucleation
| Autor: | Harshita Kumari, Shuo Qian, Arnab Dawn, Christopher D. Jones, Dimitrii S. Yufit, Marzieh Mirzamani, Jonathan W. Steed |
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| Jazyk: | angličtina |
| Předmět: |
Chemistry
Supramolecular chemistry Nucleation 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Small-angle neutron scattering 0104 chemical sciences law.invention Chemical engineering Solid-state nuclear magnetic resonance law Phase (matter) Crystallization 0210 nano-technology Single crystal Powder diffraction |
| Zdroj: | Soft matter, 2018, Vol.14(46), pp.9489-9497 [Peer Reviewed Journal] Soft Matter |
| ISSN: | 1744-6848 1744-683X |
| DOI: | 10.1039/c8sm01916a |
| Popis: | Supramolecular gel phase crystallization offers a new strategy for drug polymorph screening and discovery. In this method, the crystallization outcome depends on the interaction between solute and gel fibre. While supramolecular gels have shown success in producing new polymorphs and crystals with novel morphologies, role of the gel and nature of gel–solute interaction remains largely unexplored. The present study aims to provide a comprehensive picture of the structural evolution of a supramolecular gel produced from a bis(urea) based gelator (G) in the presence of a polymorphic drug carbamazepine (CBZ). The structural aspects of the gel have been assessed by single crystal X-ray analysis, X-ray powder diffraction (XRPD) and solid state NMR spectroscopy. Small Angle Neutron Scattering (SANS) has been used to follow the changes in gel structure in the presence of CBZ. Visual evidence from morphological study and structural evolution observed at a macroscopic level from rheological measurements, shows good agreement with the SANS results. The concentration of the gelator and the relative proportion of G to CBZ were found to be crucial factors in determining the competitive nucleation events involving gelation and crystallization. At a critical G to CBZ ratio the effect of CBZ on gel structure was maximum and fiber bundling in the gel was found to be critically affected. This study offers important information about how the interplay of gelator assembly and gel–solute interactions can fine-tune the nucleation events in a supramolecular gel phase crystallization. |
| Databáze: | OpenAIRE |
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