Skeletal muscle mass and risk of advanced adenoma in surveillance colonoscopy
| Autor: | Soo-Kyung Park, Dong Il Park, Kyung Mo Yoo, Jung Ho Park, Yoon Suk Jung, Chong Il Sohn, Hyo-Joon Yang |
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| Rok vydání: | 2020 |
| Předmět: |
Adenoma
Adult Male Risk medicine.medical_specialty Sarcopenia Time Factors Colonoscopy Colorectal adenoma Gastroenterology Cohort Studies 03 medical and health sciences 0302 clinical medicine Interquartile range Internal medicine medicine Humans Muscle Skeletal Inflammation Hepatology medicine.diagnostic_test business.industry Incidence Hazard ratio Middle Aged medicine.disease 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Female Metabolic syndrome Insulin Resistance Neoplasm Recurrence Local business Colorectal Neoplasms Cohort study Follow-Up Studies |
| Zdroj: | Journal of gastroenterology and hepatologyReferences. 35(12) |
| ISSN: | 1440-1746 |
| Popis: | BACKGROUND AND AIM Sarcopenia has been suggested to be associated with chronic inflammation and insulin resistance. This study aimed to evaluate whether low muscle mass is associated with the incidence and recurrence of advanced colorectal adenoma. METHODS We conducted a cohort study including 14 701 participants who underwent first-time screening colonoscopy between 2003 and 2012 and follow-up colonoscopy until 2017. Skeletal muscle mass was measured using a bioelectrical impedance analyzer and divided by body weight to calculate the skeletal muscle mass index (SMI). RESULTS During a median 47 (interquartile range, 35-58) months of follow-up, overall and advanced adenoma developed in 2988 (20.3%) and 207 (1.41%) participants, respectively. In multivariate analysis using models adjusted for baseline adenoma risk, lifestyle factors, markers for insulin resistance and chronic inflammation, and metabolic syndrome, decreasing SMI quartiles were associated with increased risk of occurrence of advanced adenoma and overall adenoma. The adjusted hazard ratios (95% confidence intervals) comparing SMI quartiles 3, 2, and 1 to quartile 4 were 1.57 (1.03-2.41), 1.22 (0.78-1.92), and 1.77 (1.13-2.76), respectively, for advanced adenoma (P for trend = 0.049) and 1.05 (0.95-1.17), 1.09 (0.98-1.21), and 1.26 (1.13-1.41), respectively, for overall adenoma (P for trend |
| Databáze: | OpenAIRE |
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