Favorable Outcome After Adjuvant Involved-Field Radiotherapy After Autologous Hematopoietic Stem-Cell Transplantation in Patients With High-Risk Relapsed/Refractory Lymphoma: A Single-Center Experience
| Autor: | Eshrak Al Shaibani, Hani Al Hashmi, Khalid Al Anezi, John Apostolidis, Panayotis Kaloyannidis, Ahmed Buali, Taghreed Hindi, Rawan Omari, Ayed Garni, Eman Eldebawy, Heba Raslan |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Adolescent Lymphoma medicine.medical_treatment Hematopoietic stem cell transplantation Disease Single Center Transplantation Autologous Time-to-Treatment Young Adult 03 medical and health sciences 0302 clinical medicine Refractory Internal medicine medicine Humans Aged Retrospective Studies business.industry Hematopoietic Stem Cell Transplantation Hematology Middle Aged medicine.disease Survival Rate Radiation therapy 030220 oncology & carcinogenesis Cohort Female Radiotherapy Adjuvant Neoplasm Recurrence Local business Adjuvant Follow-Up Studies 030215 immunology |
| Zdroj: | Clinical Lymphoma Myeloma and Leukemia. 21:e112-e119 |
| ISSN: | 2152-2650 |
| DOI: | 10.1016/j.clml.2020.08.028 |
| Popis: | Background and purpose: Patients with refractory or relapsed lymphoma diagnosed with bulky disease at relapse or with residual disease post salvage treatment are considered to have dismal outcome, even post autologous hematopoietic stem cell transplantation, due to disease recurrence. To minimize post-transplant relapse risk, involved field radiotherapy either to sites of bulky or localized residual disease has been utilized; however, the ideal timing for irradiation remains controversial. The aim of this study was to assess the safety and efficacy of involved field radiotherapy in the early post- transplant period. Materials and methods We retrospectively evaluated the outcome of 24 autografted patients with relapsed/refractory lymphoma who presented with bulky disease at relapse or had a persistent localized residual mass post-salvage treatment and consolidated with involved field irradiation within 4 months after autografting. Results No significant toxicity was noticed during the early post-radiotherapy period, while graft function was not impaired. After a median follow-up of 3 years for survivors, 21 patients are alive, 19 of whom are event-free, while 2 patients succumbed to disease recurrence and 1 to treatment-related myelodysplastic syndrome. The 3-year overall, lymphoma relapse-free and event-free survival rates were 86%, 86% and 82%, respectively. Conclusions Taking into consideration the poor-risk features of the study cohort, early post autologous hematopoietic stem cell transplantation involved field radiotherapy showed a safe and well-tolerated toxicity profile and demonstrated long-term effective tumor control as reflected in the promising survival rates. |
| Databáze: | OpenAIRE |
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