Myocardial infarction before and after the age of 45: Possible role of platelet receptor polymorphisms
| Autor: | Virgínia Carvalhais, Bárbara Mesquita, Paula Pinto, Patrícia Napoleão, Claudia Escórcio, Paulo F. Silva, Begoña Criado, Luís Bernardo Pina-Cabral, Teresa Pinheiro, Maria Céu Monteiro, António Almeida-Dias |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system Adolescent Myocardial Infarction Minisatellite Repeats 030204 cardiovascular system & hematology Gastroenterology Polymorphism Single Nucleotide 03 medical and health sciences Young Adult 0302 clinical medicine Polymorphism (computer science) Risk Factors Internal medicine Genotype Medicine Humans Statistical analysis Myocardial infarction Genetic Association Studies General Environmental Science Aged business.industry Integrin beta3 Middle Aged medicine.disease Platelet receptor Receptors Purinergic P2Y12 GP1BA 030228 respiratory system Platelet Glycoprotein GPIb-IX Complex lcsh:RC666-701 Case-Control Studies General Earth and Planetary Sciences Population study Female Restriction fragment length polymorphism Cardiology and Cardiovascular Medicine business |
| Zdroj: | Revista Portuguesa de Cardiologia (English Edition), Vol 37, Iss 9, Pp 727-735 (2018) Revista Portuguesa de Cardiologia, Vol 37, Iss 9, Pp 727-735 (2018) |
| ISSN: | 2174-2049 |
| Popis: | Introduction: We examined the potential role of polymorphisms of the platelet genes GP1BA (rs2243093, rs6065 and VNTR), ITGB3 (rs5918), ITGA2 (rs938043469) and P2RY12 (rs2046934, rs6801273 and rs6798347) as risk factors for myocardial infarction (MI). Methods: The study population was divided into three groups: controls (n=235), MI at age ≤45 years (MI ≤45, n=44), and MI at age >45 years (MI >45, n=78). The control group was further divided into two subgroups (control ≤45 and >45), and subgroups including only men were also considered for statistical analysis. Polymorphisms were detected by polymerase chain reaction and restriction fragment length polymorphism analysis. Results: Regarding non-genetic risk factors, the control group differed statistically from the MI ≤45 group (p45 group (p45 was compared with the control group, with a higher risk of MI in the TT genotype (OR 2.852; 95% CI: 1.092-7.451; p=0.032). In the GP1BA rs6065 polymorphism, a statistically significant difference was found between control ≤45 only men and MI ≤45 only men, with a higher risk in the CT genotype (OR 5.568; 95% CI: 1.421-21.822; p=0.016), despite the low numbers included. The other polymorphisms studied did not show any statistically significant correlations. Conclusion: There is a statistically significant association between the TT genotype of the ITGA2 rs938043469 polymorphism and increased risk for MI >45. Resumo: Introdução: Determinou-se o papel de polimorfismos dos genes de expressão plaquetária GP1BA (rs2243093, rs6065 e o VNTR p.Ser415_Thr428(0_4)), ITGB3 (rs5918), ITGA2 (rs938043469) e P2RY12 (rs2046934, rs6801273 e rs6798347) como fatores de risco para o enfarte agudo do miocárdio (EAM). Métodos: A amostra foi dividida em três grupos: Controlo (n=235), EAM ≤45 anos (n=44) e EAM >45 anos (n=78). O grupo Controlo foi ainda dividido em dois subgrupos (Controlo ≤45 e >45). Subgrupos incluindo somente homens também foram considerados para fins estatísticos. Os polimorfismos foram estudados através de PCR e RFLP. Resultados: Em relação aos fatores de risco não genéticos, o grupo Controlo diferia estatisticamente do grupo EAM ≤ 45 anos (p45 anos (p45 anos e Controlo, associando-se o genótipo TT a aumento de risco de EAM (OR 2,852; IC 95% de 1,092 a 7,451; p=0,032). No polimorfismo rs6065 do gene GP1BA foi encontrada uma diferença estatística quando comparados os grupos Controlo ≤ 45 só homens e EAM ≤ 45 só homens, associando-se o genótipo C/T a um maior risco de EAM (OR 5,568; IC 95% de 1,421 a 21,822; p=0,016), apesar do baixo n. Os outros polimorfismos não apresentaram correlação significativa. Conclusão: Existe uma associação estatística significativa entre o genótipo T/T do polimorfismo rs938043469 do gene ITGA2 e o risco de EAM >45. Keywords: Myocardial infarction and platelet polymorphisms, GPIb-V-IX, GPIa-IIa, GPIIb-IIIa: ADP P2Y12 receptor, Palavras-chave: Enfarte agudo do miocárdio e polimorfismos plaquetários, GP Ib-V-IX, GP Ia-IIa, GP IIb-IIIa, ADP P2Y12 receptor |
| Databáze: | OpenAIRE |
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