Higher Order Visual Areas Enhance Stimulus Responsiveness in Mouse Primary Visual Cortex
| Autor: | Matthijs N. oude Lohuis, Umberto Olcese, Cyriel M. A. Pennartz, Alexis Cervan Canton |
|---|---|
| Přispěvatelé: | Cognitive and Systems Neuroscience (SILS, FNWI), SILS Other Research (FNWI) |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Visual perception
genetic structures Cognitive Neuroscience media_common.quotation_subject Optogenetics Stimulus (physiology) Biology Visual processing Mice Cellular and Molecular Neuroscience Primary Visual Cortex medicine Animals Contrast (vision) Visual Pathways Visual Cortex media_common Neurons eye diseases Visual cortex medicine.anatomical_structure Order (biology) Receptive field Visual Perception Neuroscience Photic Stimulation |
| Zdroj: | Cerebral Cortex, 32(15), 3269-3288. Oxford University Press Cerebral Cortex |
| ISSN: | 1047-3211 |
| Popis: | Over the past few years, the various areas that surround the primary visual cortex (V1) in the mouse have been associated with many functions, ranging from higher order visual processing to decision-making. Recently, some studies have shown that higher order visual areas influence the activity of the primary visual cortex, refining its processing capabilities. Here, we studied how in vivo optogenetic inactivation of two higher order visual areas with different functional properties affects responses evoked by moving bars in the primary visual cortex. In contrast with the prevailing view, our results demonstrate that distinct higher order visual areas similarly modulate early visual processing. In particular, these areas enhance stimulus responsiveness in the primary visual cortex, by more strongly amplifying weaker compared with stronger sensory-evoked responses (for instance specifically amplifying responses to stimuli not moving along the direction preferred by individual neurons) and by facilitating responses to stimuli entering the receptive field of single neurons. Such enhancement, however, comes at the expense of orientation and direction selectivity, which increased when the selected higher order visual areas were inactivated. Thus, feedback from higher order visual areas selectively amplifies weak sensory-evoked V1 responses, which may enable more robust processing of visual stimuli. |
| Databáze: | OpenAIRE |
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