A double-blind evaluation of topical capsaicin in pruritic psoriasis
| Autor: | Brenda J. Berberian, Ira H. Rex, Virginia I. Sulica, H. Irving Katz, Michael Jarratt, Charles Ellis, Gerald G. Krueger, W. Alan Dodd, Steven E. Prawer, John E. Wolf |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Side effect Erythema Adolescent medicine.medical_treatment Administration Topical Substance P Dermatology chemistry.chemical_compound Double-Blind Method Psoriasis medicine Humans Burning Sensation Aged Chemotherapy business.industry Pruritus Middle Aged medicine.disease Pathophysiology chemistry Capsaicin Female medicine.symptom business |
| Zdroj: | Journal of the American Academy of Dermatology. 29(3) |
| ISSN: | 0190-9622 |
| Popis: | Background: Substance P, an undecapeptide neurotransmitter, has been implicated in the pathophysiology of psoriasis and pruritus. Objective: Safety and efficacy of topical capsaicin, a potent substance P depletor, were evaluated in patients with pruritic psoriasis. Methods: Patients applied capsaicin 0.025% cream (n = 98) or vehicle (n = 99) four times a day for 6 weeks in this double-blind study. Efficacy was based on a physician's global evaluation and a combined psoriasis severity score including scaling, thickness, erythema, and pruritus. Results: Capsaicin-treated patients demonstrated significantly greater improvement in global evaluation (p = 0.024 after 4 weeks and p = 0.030 after 6 weeks) and in pruritus relief (p = 0.002 and p = 0.060, respectively), as well as a significantly greater reduction in combined psoriasis severity scores (p = 0.030 and p = 0.036, respectively). The most frequently reported side effect in both treatment groups was a transient burning sensation at application sites. Conclusion: Topically applied capsaicin effectively treats pruritic psoriasis, a finding that supports a role for substance P in this disorder. |
| Databáze: | OpenAIRE |
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