Detection of KIT mutations in core binding factor acute myeloid leukemia
| Autor: | Dalia Negm Eldin, Nayera Hamdy, Bahia Y. Riad, Passant Badr, Ghada M. Elsayed |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty FLT-3-ITD FLT3 internal tandem duplication lcsh:RC254-282 Gastroenterology Article 03 medical and health sciences CBF-AML 0302 clinical medicine hemic and lymphatic diseases Internal medicine medicine Leukocytosis NCCN National comprehensive cancer network Core binding factor acute myeloid leukemia ELN European Leukemia Network FLT-3 mutations business.industry Significant difference Hematology KIT mutations lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens PCR-RFLP Polymerase chain reaction restriction fragment length polymorphism HRM High resolution melting curve analysis 030104 developmental biology Oncology 030220 oncology & carcinogenesis cardiovascular system medicine.symptom business HRM analysis CBF-AML core binding factor AML circulatory and respiratory physiology |
| Zdroj: | Leukemia Research Reports Leukemia Research Reports, Vol 10, Iss, Pp 20-25 (2018) |
| ISSN: | 2213-0489 |
| DOI: | 10.1016/j.lrr.2018.06.004 |
| Popis: | We have investigated the frequency and the effect of KIT mutations on the outcome of patients with CBF-AML. 69 patients (34 pediatrics and 35 adults) with CBF-AML were enrolled in the study. The frequency of KIT mutations was higher in adults compared to pediatrics (22.9% and 14.7%, p = 0.38) respectively. Leukocytosis ≥ 20 × 109 /L was significantly associated with pediatrics compared to adults. t(8;21)(q22;22) was significantly associated with thrombocytopenia in adults. We conclude that no significant difference is found between KIT mutated and unmutated CBF-AML in adults and pediatrics. Children with CBF-AML present with leukocytosis. t(8;21) is associated with thrombocytopenia. Keywords: CBF-AML, KIT mutations, FLT-3 mutations, HRM analysis |
| Databáze: | OpenAIRE |
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