Ventilatory response of goats to transient changes in CO2 and O2 during acute hypoxia
| Autor: | Curtis A. Smith, Ralph H. Kellogg |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Physiology Peripheral chemoreceptors Acute hypoxia Medicine Animals Humans Hypoxia Carotid Body business.industry Goats Respiration Carbon Dioxide Middle Aged Hypoxic gas mixture Chemoreceptor Cells Oxygen Breath Tests Anesthesia Time course Female medicine.symptom business Hypercapnia |
| Zdroj: | Respiration physiology. 24(2) |
| ISSN: | 0034-5687 |
| Popis: | The authors assessed the relative sensitivity of the peripheral chemoreceptors of 4 goats to a transient decrease in inspired CO 2 using a 2-breath test. This test provides a steady-state background of hypoxia ana hypercapnia and then, for 2 breaths, an equally hypoxic gas mixture containing no CO 2 . Another type of 2-breath test, providing 2 breaths of a hyperoxic gas mixture against a background of hypoxia, was used to establish the time course of a response known to come from peripheral chemoreceptors. Seven human subjects were studied in a similar fashion to establish the validity of the procedure. Except for 2 responses, the author's human data agree with those reported previously by others. All 4 goats resembled man in responding to removal of hypoxia with a significant decrease in ventilation, but 3 of the 4 goats, unlike man, showed no significant decrease in ventilation when CO 2 was removed. The authors conclude that the peripheral chemoreceptors of goats are commonly insensitive to transient changes in inspired CO 2 during acute hypoxia. |
| Databáze: | OpenAIRE |
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