Impact of Cerebral Radiofrequency Exposures on Oxidative Stress and Corticosterone in a Rat Model of Alzheimer's Disease

Autor: Anne-Sophie Villégier, Marc Bouji, Kelly Blazy, Anthony Lecomte, Christelle Gamez
Přispěvatelé: Institut National de l'Environnement Industriel et des Risques (INERIS), Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de l'Environnement Industriel et des Risques
Rok vydání: 2019
Předmět:
0301 basic medicine
medicine.medical_specialty
Rodent
Radio Waves
Radial maze
Rat model
Plaque
Amyloid
Disease
Hippocampal formation
MOBILE PHONE
medicine.disease_cause
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Electromagnetic Fields
Corticosterone
Alzheimer Disease
Internal medicine
biology.animal
medicine
RADIOFREQUENCY
Dementia
Animals
Rats
Long-Evans
Maze Learning
Spatial Memory
Memory Disorders
biology
business.industry
General Neuroscience
MEMORY
General Medicine
medicine.disease
Rats
Psychiatry and Mental health
Clinical Psychology
Oxidative Stress
030104 developmental biology
Endocrinology
chemistry
ALZHEIMER'S DISEASE
[SDV.TOX]Life Sciences [q-bio]/Toxicology
Heme Oxygenase (Decyclizing)
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Oxidative stress
Cell Phone
Zdroj: Journal of Alzheimer's Disease
Journal of Alzheimer's Disease, IOS Press, 2020, 73 (2), pp.467-476. ⟨10.3233/JAD-190593⟩
ISSN: 1875-8908
1387-2877
DOI: 10.3233/JAD-190593⟩
Popis: Background Alzheimer's disease (AD) is the most common type of neurodegenerative disease leading to dementia. Several studies suggested that mobile phone radiofrequency electromagnetic field (RF-EMF) exposures modified AD memory deficits in rodent models. Objective Here we aimed to test the hypothesis that RF-EMF exposure may modify memory through corticosterone and oxidative stress in the Samaritan rat model of AD. Methods Long-Evans male rats received intracerebroventricular infusion with ferrous sulphate, amyloid-beta 1-42 peptide, and buthionine-sufloximine (AD rats) or with vehicle (control rats). To mimic cell phone use, RF-EMF were exposed to the head for 1 month (5 days/week, in restraint). To look for hazard thresholds, high brain averaged specific absorption rates (BASAR) were tested: 1.5 W/Kg (15 min), 6 W/Kg (15 min), and 6 W/Kg (45 min). The sham group was in restraint for 45 min. Endpoints were spatial memory in the radial maze, plasmatic corticosterone, heme oxygenase-1 (HO1), and amyloid plaques. Results Results indicated similar corticosterone levels but impaired memory performances and increased cerebral staining of thioflavine and of HO1 in the sham AD rats compared to the controls. A correlative increase of cortical HO1 staining was the only effect of RF-EMF in control rats. In AD rats, RF-EMF exposures induced a correlative increase of hippocampal HO1 staining and reduced corticosterone. Discussion According to our data, neither AD nor control rats showed modified memory after RF-EMF exposures. Unlike control rats, AD rats showed higher hippocampal oxidative stress and reduced corticosterone with the higher BASAR. This data suggests more fragility related to neurodegenerative disease toward RF-EMF exposures.
Databáze: OpenAIRE
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