Association of serum fibroblast growth factor-23 with Doppler pulse wave velocity in hemodialysis patients

Autor: Ahmad B Ahmad, Walaa H. Ibrahim, Noha G Sayed
Rok vydání: 2018
Předmět:
Male
Fibroblast growth factor 23
030232 urology & nephrology
lcsh:Medicine
Blood Pressure
030230 surgery
0302 clinical medicine
Risk Factors
Medicine
Pulse wave velocity
Age Factors
General Medicine
Middle Aged
Femoral Artery
Ultrasonography
Doppler
Pulsed
cardiovascular system
symbols
Cardiology
Female
Doppler effect
circulatory and respiratory physiology
Adult
medicine.medical_specialty
Adolescent
Pulse Wave Analysis
Carotid Artery
Common
Risk Assessment
Peripheral Arterial Disease
Young Adult
03 medical and health sciences
QRS complex
symbols.namesake
Vascular Stiffness
Right Common Carotid Artery
Predictive Value of Tests
Renal Dialysis
Internal medicine
Humans
cardiovascular diseases
Renal Insufficiency
Chronic
Aged
business.industry
lcsh:R
medicine.disease
Fibroblast Growth Factors
Fibroblast Growth Factor-23
Cross-Sectional Studies
Blood pressure
Arterial stiffness
business
Biomarkers
Zdroj: Saudi Journal of Kidney Diseases and Transplantation, Vol 29, Iss 1, Pp 95-100 (2018)
ISSN: 1319-2442
Popis: We aimed to study the association of fibroblast growth factor-23 (FGF-23) as a novel cardiovascular risk factor with Doppler pulse wave velocity (PWV) as an arterial stiffness measuring tool in hemodialysis (HD) patients. We conducted a cross-sectional study in which blood samples from 86 HD patients were obtained to estimate FGF 23 and other parameters. Flow waveforms were obtained at two locations within right common carotid artery, and right femoral artery by Doppler ultrasound with ECG recorded in addition. The time differences between the R wave of the ECG signal and the onset of the flow waveforms at the two sites yield ΔT. Distances between sampling sites were measured using a tape measure. PWV was defined as (m/s) = D (m)/ ΔT (s). In the current study, we found significant positive correlations between Doppler PWV and both age (r = 0.401, P = 0.039) and systolic blood pressure (r = 0.602, P = 0.034), while no significant association between Doppler PWV and FGF-23 (r = 0.123, P = 0.259) could be detected. Serum FGF-23 levels are not significantly associated with Doppler PWV in HD patients.
Databáze: OpenAIRE
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