Polysaccharides with Antitumor Effect in Breast Cancer: A Systematic Review of Non-Clinical Studies
| Autor: | Elizabeth S. Fernandes, Virgilio Frota Rossato, Leonardo Moura Cordeiro, Claudia Rita Corso, Daniele Maria-Ferreira, Karien Sauruk da Silva, Natalia Mulinari Turin de Oliveira, Suzany Hellen da Silva Soczek |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology Risk medicine.medical_specialty Angiogenesis MEDLINE nonclinical studies Antineoplastic Agents Breast Neoplasms Polysaccharide cancer treatment 03 medical and health sciences chemistry.chemical_compound breast cancer 0302 clinical medicine Breast cancer In vivo Polysaccharides Internal medicine Medicine Animals Humans TX341-641 chemistry.chemical_classification Nutrition and Dietetics Nutrition. Foods and food supply business.industry Fucoidan medicine.disease In vitro 030104 developmental biology Systematic review chemistry 030220 oncology & carcinogenesis Female Systematic Review natural source business Publication Bias Food Science |
| Zdroj: | Nutrients Nutrients, Vol 13, Iss 2008, p 2008 (2021) |
| ISSN: | 2072-6643 |
| Popis: | Purpose: To review the effects of polysaccharides and their proposed mechanisms of action in breast cancer experimental models. Data sources, selection, and extraction: Articles were selected by using PubMed, ScienceDirect, Scopus, and Medline, assessed from 1 May 2019 to 1 July 2020. The systematic review was registered in the International Prospective Register of Systematic Reviews (Prospero) under the number CRD42020169103. Results: Most of the studies explore algae polysaccharides (43.2%), followed by mushrooms (13.5%), plants (13.5%), fruits (10.8%), fungus (2.7%), bacteria, (2.7%), and sea animals (2.7%). A total of 8.1% investigated only in vitro models, 62.1% evaluated only in vivo models, and 29.7% evaluated in vitro and in vivo models. The mechanism of action involves apoptosis, inhibition of cellular proliferation, angiogenesis, and antimetastatic effects through multiple pathways. Conclusions: Findings included here support further investigations on the anti-tumor effect of polysaccharides. Some polysaccharides, such as fucoidan and β-glucans, deserve detailed and structured studies aiming at translational research on breast tumors, since they are already used in the clinical practice of other proposals of human health. |
| Databáze: | OpenAIRE |
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