Isolated itching of external auditory canal: clinicopathological study with immunohistochemical determination of antimicrobial peptides
| Autor: | Serpil Oguztuzun, Baran Acar, Murat Zaim, G Güler Simsek, R. Murat Karasen |
|---|---|
| Přispěvatelé: | Kırıkkale Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Pathology Biopsy medicine.medical_treatment Antimicrobial peptides Cathelicidin Auditory canal medicine Humans Prospective Studies Treatment Failure medicine.diagnostic_test business.industry External Auditory Canal Pruritus Age Factors Anatomical pathology General Medicine Middle Aged medicine.disease Otitis Externa Immunohistochemistry Otorhinolaryngology Case-Control Studies Dermatitis Allergic Contact Skin biopsy Itching Female medicine.symptom business Contact dermatitis Ear Canal Antimicrobial Cationic Peptides |
| ISSN: | 0022-2151 |
| Popis: | Objective:This study aimed to demonstrate the histological and immunohistological features of skin biopsy specimens from patients complaining of isolated itching of the external auditory canal.Materials and methods:A prospective, case–control study was performed of 24 patients undergoing evaluation for contact dermatitis of the external auditory canal, and 24 controls. Skin biopsies were examined histologically by a single, blinded dermatopathologist, using light microscopy, to determine histopathological characteristics. The immunohistological presence of the antimicrobial peptides human β-defensin-3 and LL-37 cathelicidin was also assessed. Findings for patients and controls were compared.Results:There was a statistically significant difference in the degree of inflammation, comparing patients and controls (p p > 0.05). Furthermore, the patients' skin biopsies did not show pronounced expression of human β-defensin-3 or LL-37 cathelicidin.Conclusion:Histological and immunohistological examination of skin biopsies from cases of isolated itching of the external auditory canal did not support a diagnosis of dermatitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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