Prognostic value of the combined expression of tumor-associated trypsin inhibitor (TATI) and p53 in patients with bladder cancer undergoing radical cystectomy

Autor: Chuanliang Xu, Xu Gao, Anwei Liu, Zhensheng Zhang, Fei Liu, Yongping Xue, Haoyuan Tan, Shuxiong Zeng, Yinghao Sun, Qiao Xiong
Rok vydání: 2019
Předmět:
Oncology
Male
Cancer Research
medicine.medical_specialty
Multivariate analysis
medicine.medical_treatment
Urinary Bladder
Value (computer science)
Disease
Kaplan-Meier Estimate
Cystectomy
Internal medicine
Genetics
medicine
Biomarkers
Tumor
Humans
0501 psychology and cognitive sciences
In patient
Tumor-Associated Trypsin Inhibitor
0505 law
Aged
Neoplasm Staging
Retrospective Studies
Carcinoma
Transitional Cell
Tissue microarray
Bladder cancer
business.industry
05 social sciences
General Medicine
Middle Aged
medicine.disease
Prognosis
Progression-Free Survival
Survival Rate
Urinary Bladder Neoplasms
Tissue Array Analysis
Trypsin Inhibitor
Kazal Pancreatic
050501 criminology
Disease Progression
Female
Neoplasm Grading
Tumor Suppressor Protein p53
business
050104 developmental & child psychology
Follow-Up Studies
Zdroj: Cancer biomarkers : section A of Disease markers. 26(3)
ISSN: 1875-8592
Popis: Background Urothelial carcinoma of the bladder is a heterogeneous disease for which reliable prognostic molecular biomarkers have not been established. Objective To investigate the prognostic value of tumor-associated trypsin inhibitor (TATI) expression combined with p53 expression in bladder cancer patients who have undergone radical cystectomy. Methods Tissue microarrays from 110 patients were analyzed immunohistochemically for TATI and p53 protein expression. Complete clinical-pathological information and follow-up data were collected. Univariable Kaplan-Meier analysis and log-rank test were performed to assess the association between TATI and p53 expression patterns with clinical outcomes. Cox's proportional hazard analysis was performed to identify potential independent risk factors for predicting disease progression and evaluate the prognostic value of combining the expression of TATI and p53 on progression-free survival (PFS) and overall survival (OS). Results TATI expression was positively correlated with favorable differentiation of bladder cancer, and lower tumor stage. p53 expression was positively related to tumor stage, tumor grade, and lymph-node invasion. Univariate Kaplan-Meier analysis revealed significant differences between TATI-positive vs. TATI-negative and p53-positive vs. p53-negative patients, regarding PFS. Multivariate analysis showed that both TATI and p53 expression were independent factors for predicting disease progression. Conclusion TATI expression patterns could enhance the prognostic value of p53 overexpression on progression.
Databáze: OpenAIRE
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