Low bone mineral density and associated factors in patients with haemophilia in Colombia

Autor:	C L Sossa Melo, M L Ortiz, David Leonardo Reyes, Angela María Peña, Sara Ines Jimenez, K Morales, Maria Luna-Gonzalez, E. A. Wandurraga, Claudia Marcela Chalela, Luis Antonio Salazar, Miguel Ochoa, M Ayala-Castillo
Rok vydání:	2018
Předmět:	Adult Male medicine.medical_specialty Adolescent Haemophilia A Osteoporosis Population 030209 endocrinology & metabolism Colombia 030204 cardiovascular system & hematology Hemophilia A Haemophilia Hemophilia B Young Adult 03 medical and health sciences 0302 clinical medicine Bone Density Internal medicine Arthropathy medicine Humans Child education Genetics (clinical) Femoral neck Bone mineral education.field_of_study business.industry Infant Newborn Infant Hematology General Medicine Middle Aged medicine.disease medicine.anatomical_structure Case-Control Studies Child Preschool Female business Body mass index
Zdroj:	Haemophilia. 24:e222-e229
ISSN:	1351-8216
DOI:	10.1111/hae.13516
Popis:	Introduction Patients with haemophilia may have lower levels of bone mineral density (BMD) compared with the general population. Moreover, haemophilic patients have increased risk factors for low bone mineral density (LBMD) such as arthropathy and resulting immobility, increasing their risk for osteoporosis and fractures. Aim To assess the prevalence of LBMD and associated risk factors among a group of Colombian haemophilic patients. Methods In this case-control study, 90 patients with haemophilia A and B, over the age of five, were recruited. Controls were healthy participants matched by age, gender, body mass index (BMI), socioeconomic status, and race. All participants underwent dual energy X-ray absorptiometry (DXA) and the Global Physical Activity Questionnaire. Blood tests were collected to evaluate LBMD determinants in cases. Results BMD was lower in cases than in the control group. BMD of femoral necks was 0.907 g/cm2 in cases vs. 1.020 g/cm2 in controls (P = .019), and BMD of hips 0.930 g/cm2 in cases vs. 1030 g/cm2 in controls (P = .019). The greater the severity of haemophilia, the lower BMD in spine, femoral neck, and hips. Elevated C-protein levels were found in 44.1% of patients with LBMD and 14.8% with normal BMD (P = .003). The study found an adjusted prevalence ratio of 2.11, indicating that haemophilic patients are two times more likely to have LBMD (CI95% = 1.43-3.11 P Conclusion Results from the present study showed that haemophilia was associated with a higher frequency of LBMD. Severity of haemophilia, haemophilic arthropathy, and elevated C-reactive protein levels was directly associated with LBMD.
Databáze:	OpenAIRE
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