Genotypes and clinical aspects associated with bone mineral density in Argentine postmenopausal women
| Autor: | Arturo Alisio, Adriana Pérez, Eliana Elías, María Lavezzo, Miriam Binci, V. Centeno, M.A. Rivoira, María Rosa Ulla, Beatriz A. García, Nori Tolosa de Talamoni |
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| Rok vydání: | 2007 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Genotype medicine.drug_class Endocrinology Diabetes and Metabolism Population Osteoporosis Argentina Calcitriol receptor Body Mass Index Endocrinology Gene Frequency Bone Density Internal medicine medicine Humans Orthopedics and Sports Medicine Genetic Predisposition to Disease education Femoral neck Bone mineral education.field_of_study Lumbar Vertebrae Polymorphism Genetic biology business.industry Femur Neck Body Weight General Medicine Middle Aged medicine.disease FokI Body Height Peptide Fragments Postmenopause medicine.anatomical_structure Receptors Estrogen Estrogen biology.protein Receptors Calcitriol Female business Body mass index Procollagen |
| Zdroj: | Journal of bone and mineral metabolism. 26(4) |
| ISSN: | 0914-8779 |
| Popis: | The aim of this study was to determine genotypes and clinical aspects associated with bone mineral density (BMD) in postmenopausal women from Cordoba, Argentina. Polymorphisms were assessed by RFLP-PCR technique using BsmI and FokI for vitamin D receptor gene (VDR) and XbaI and PvuII for estrogen receptor-α gene (ERα) as restrictases. Sixty-eight healthy, 54 osteopenic, and 64 osteoporotic postmenopausal women were recruited. Femoral neck and lumbar spine BMD were inversely correlated with age in the entire analyzed population. Height was lower in osteopenic and osteoporotic women as compared to healthy women (P < 0.05). Weight and body mass index (BMI) were the lowest in osteoporotic women (P < 0.01 versus healthy group). Serum procollagen type I Nterminal propeptide (PINP) was higher in osteoporotic women as compared to the other groups. Distribution of VDR and ERα genotypes was similar in the three groups. Genotype bb (VDR) was associated with low values of lumbar BMD in the healthy group (P < 0.05 versus genotype Bb), and with low values of femoral BMD (P < 0.05 versus genotype BB) in osteoporotic women. BB*Pp interaction was associated with the highest femoral neck BMD (P < 0.05), whereas the bb*xx interaction was associated with the lowest femoral neck BMD in the total population analyzed (P < 0.05). In conclusion, parameters such as age, height, weight, BMI, serum PINP, VDR genotypes, and interactions between VDR and ERa genotypes could be useful to predict a decrease in BMD in Argentine postmenopausal women. |
| Databáze: | OpenAIRE |
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