Critical role of hippocampal muscarinic acetylcholine receptors on memory reconsolidation in mice
| Autor: | J. Millan, Mariano Guillermo Blake, Mariano Martín Boccia, Maria del Carmen Krawczyk |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Cognitive Neuroscience Scopolamine Experimental and Cognitive Psychology Muscarinic Antagonists Biology Hippocampal formation Muscarinic Agonists Hippocampus 050105 experimental psychology 03 medical and health sciences Behavioral Neuroscience Mice 0302 clinical medicine Muscarinic acetylcholine receptor medicine Avoidance Learning Animals 0501 psychology and cognitive sciences Acetylcholine receptor Memory Consolidation Oxotremorine 05 social sciences Pirenzepine Solifenacin Succinate Receptors Muscarinic Nicotinic agonist Metabotropic receptor Memory consolidation Neuroscience 030217 neurology & neurosurgery Acetylcholine medicine.drug Ionotropic effect |
| Zdroj: | Neurobiology of learning and memory. 177 |
| ISSN: | 1095-9564 |
| Popis: | Over the years, experimental and clinical evidence has given support to the idea that acetylcholine (Ach) plays an essential role in mnemonic phenomena. On the other hand, the Hippocampus is already known to have a key role in learning and memory. What is yet unclear is how the Ach receptors may contribute to this brain region role during memory retrieval. The Ach receptors are divided into two broad subtypes: the ionotropic nicotinic acetylcholine receptors and the metabotropic muscarinic acetylcholine receptors. Back in 2010, we demonstrated for the first time the critical role of hippocampal α7 nicotinic acetylcholine receptors in memory reconsolidation process of an inhibitory avoidance response in mice. In the present work, we further investigate the possible implication of hippocampal muscarinic Ach receptors (mAchRs) in this process using a pharmacological approach. By specifically administrating agonists and antagonists of the different mAchRs subtypes in the hippocampus, we found that M1 and M2 but not M3 subtype may be involved in memory reconsolidation processes in mice. |
| Databáze: | OpenAIRE |
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