| Autor: |
Yuanyuan Tian, Jiao Wang, Xiaori Qin, Shibing Li, Cheng Lan, Xiaoning Sun |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Cellular Immunology. 382:104631 |
| ISSN: |
0008-8749 |
| DOI: |
10.1016/j.cellimm.2022.104631 |
| Popis: |
Hepatitis is closely related to cirrhosis and liver cancer, and it is vital that we develop new drugs and identify new drug targets. Traditional Chinese medicine has demonstrated excellent curative effects on liver diseases. The ingredients from Chinese herbals are important source for drug development in the treatment of hepatitis. Here, we found that narciclasine (NCS), a major component extracted from narcissus bulbs, showed hepatoprotective effect against concanavalin A (Con A) induced hepatitis. NCS treatment significantly reduced hepatocyte death, hepatic inflammatory cells infiltration, and serum cytokine levels in Con A challenged mice. We further observed that NCS directly inhibited Con A induced splenocytes proliferation and cytokine production in vitro. RNA-seq results showed that genes related to immune response were upregulated in Con A treated CD4 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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