Cortical Brain Mapping of Peripheral Nerves Using Functional Magnetic Resonance Imaging in a Rodent Model
| Autor: | James S. Hyde, Rupeng Li, Younghoon R. Cho, Hani S. Matloub, Ji Geng Yan, Christopher P. Pawela, Anthony G. Hudetz, Marie L. Schulte, Dennis S. Kao, Matthew L. Runquist, Seth R. Jones, Safwan Jaradeh |
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| Rok vydání: | 2008 |
| Předmět: |
Sensory system
Stimulation Motor Activity Brain mapping Article Rats Sprague-Dawley Forelimb medicine Animals Efferent Pathway Ulnar Nerve Cerebral Cortex Brain Mapping medicine.diagnostic_test business.industry Somatosensory Cortex Anatomy Magnetic Resonance Imaging Electric Stimulation Electrodes Implanted Median Nerve Rats Functional imaging Musculocutaneous Nerve Models Animal Peripheral nerve injury Radial Nerve Surgery Functional magnetic resonance imaging business Brachial plexus |
| Zdroj: | Journal of Reconstructive Microsurgery. 24:551-557 |
| ISSN: | 1098-8947 0743-684X |
| DOI: | 10.1055/s-0028-1088231 |
| Popis: | The regions of the body have cortical and subcortical representation in proportion to their degree of innervation. The rat forepaw has been studied extensively in recent years using functional magnetic resonance imaging (fMRI), typically by stimulation using electrodes directly inserted into the skin of the forepaw. Here we stimulate the nerve directly using surgically implanted electrodes. A major distinction is that stimulation of the skin of the forepaw is mostly sensory, whereas direct nerve stimulation reveals not only the sensory system but also deep brain structures associated with motor activity. In this article, we seek to define both the motor and sensory cortical and subcortical representations associated with the four major nerves of the rodent upper extremity. We electrically stimulated each nerve (median, ulnar, radial, and musculocutaneous) during fMRI acquisition using a 9.4-T Bruker scanner (Bruker BioSpin, Billerica, MA). A current level of 0.5 to 1.0 mA and a frequency of 5 Hz were used while keeping the duration constant. A distinct pattern of cortical activation was found for each nerve that can be correlated with known sensorimotor afferent and efferent pathways to the rat forepaw. This direct nerve stimulation rat model can provide insight into peripheral nerve injury. |
| Databáze: | OpenAIRE |
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