Leukocyte reduction filters as an alternative source of peripheral blood leukocytes for research
| Autor: | Ali Akbar Pourfathollah, Zahra Abbasi-Malati, Shirin Ferdowsi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
business.industry
Leukocyte reduction filters Usage Hematology Leukapheresis Review Article 030204 cardiovascular system & hematology Human cell Peripheral blood 03 medical and health sciences 0302 clinical medicine Leukoreduction Blood product Healthy volunteers Immunology Immunology and Allergy Medicine Diseases of the blood and blood-forming organs Leukocyte reduction RC633-647.5 business Peripheral blood leukocytes 030215 immunology Whole blood |
| Zdroj: | Hematology, Transfusion and Cell Therapy, Vol 43, Iss 4, Pp 494-498 (2021) Hematology, Transfusion and Cell Therapy Hematology, Transfusion and Cell Therapy, Volume: 43, Issue: 4, Pages: 494-498, Published: 29 NOV 2021 |
| ISSN: | 2531-1379 |
| Popis: | Introduction Peripheral blood leukocytes are a suitable cell model for science research. However, blood samples from healthy volunteers are limited in volume and difficult to obtain due to the complexity of volunteer recruitment. Objective Therefore, it is urgent to find an alternative source of peripheral blood leukocytes. Method One of the possibilities is the use of leukocyte reduction filters (LRFs) in blood banks that is used for preparation of leukoreduced blood products. More than 90% of the leukocytes are trapped in the leukofilters allowing the desired blood product to pass through. Results It has been reported that the biological function of leukocytes collected from the filters are no different from those isolated from buffy coats, leukapheresis products and whole blood (WB) cells. Moreover, LRFs are waste products that are discarded after leukoreduction. Conclusion Thus, leukofilters represent an economic source of human cell populations that can be used for a variety of investigative purposes, with no cost. In the present study, we reviewed the different usage of LRFs in the research, clinical and commercial applications. |
| Databáze: | OpenAIRE |
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