Effect of wheat bran and flaxseed on cadmium effects and retention in rats
| Autor: | B S Hausen, Tatiana Emanuelli, Erico M.M. Flores, D. M. Kemerich, T. Diettrich, Maria da Graça Kolinski Callegaro, V. L. Dressler, E. Alves, Bruna Gressler Milbradt, Fabio A. Duarte |
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| Rok vydání: | 2010 |
| Předmět: |
Dietary Fiber
Male Cadmium Poisoning Health Toxicology and Mutagenesis chemistry.chemical_element Cadmium chloride Toxicology Kidney Kidney Function Tests Feed conversion ratio Cadmium poisoning Absorption chemistry.chemical_compound Cadmium Chloride Liver Function Tests Flax medicine Animals Fiber Food science Rats Wistar Cadmium Bran Body Weight Kidney metabolism General Medicine Organ Size medicine.disease Rats Biochemistry chemistry Liver Solubility Toxicity Seeds Environmental Pollutants Plant Preparations |
| Zdroj: | Humanexperimental toxicology. 30(8) |
| ISSN: | 1477-0903 |
| Popis: | Dietary fiber can affect cadmium (Cd) absorption and toxicity, but the effect appears to depend on the type of dietary fiber. The aim of the present study was to compare the effect of dietary sources containing distinct amounts of soluble and insoluble fiber on Cd absorption, accumulation and toxicity in growing rats. The absorption of essential macrominerals (Ca, P and Mg) was also evaluated. Animals received a nutritionally balanced diet with cellulose (cel — control), wheat bran or flaxseed as the fiber source with 0 or 50 mg Cd kg-1 diet, during 30 days. Cd exposure reduced body weight gain, feed efficiency ratio, epididymal fat relative weight and liver relative weight, and increased plasma alanine aminotransferase activity in all fiber groups. The apparent Cd absorption was similar among Cd-groups, but the flax-Cd group had a higher hepatic and renal Cd concentration. Cd decreased the absorption of Ca and P, and increased Mg absorption in the wheat bran and flaxseed groups, but not in the cel group. Although the different fiber sources investigated had no effect on Cd toxicity, the major soluble fiber source, flaxseed, increased Cd retention. Thus, caution should be taken in the intake of flaxseed by Cd-exposed populations. |
| Databáze: | OpenAIRE |
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