Serum fetuin-A levels and abdominal aortic calcification in healthy men - The STRAMBO study
| Autor: | Roland Chapurlat, Martina Rauner, Michael Schoppet, Jacqueline Benner, Pawel Szulc, Lorenz C. Hofbauer |
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| Rok vydání: | 2014 |
| Předmět: |
Fibroblast growth factor 23
Adult Male medicine.medical_specialty Histology Calcification inhibitor Physiology alpha-2-HS-Glycoprotein Endocrinology Diabetes and Metabolism Renal function Cohort Studies Young Adult Absorptiometry Photon Internal medicine medicine Humans Aorta Abdominal Vascular Calcification Aged Aged 80 and over Vascular disease business.industry Middle Aged medicine.disease Fetuin Endocrinology Cross-Sectional Studies Biomarker (medicine) business Biomarkers Hormone Calcification |
| Zdroj: | Bone. 79 |
| ISSN: | 1873-2763 |
| Popis: | Vascular calcification results from an imbalance between increased extracellular levels of calcium and phosphate, reduced solubility, and low levels of calcification inhibitors in blood or the vascular wall. Fetuin-A is a major circulating calcification inhibitor. Rodent models of fetuin-A deficit indicate its calcification inhibiting potential. Clinical studies suggest its role as a biomarker in vascular disease. This cross-sectional study was performed in a cohort of 974 men aged ≥ 40 years (average 68 years) consisting of men holding health insurance cover with Mutuelle des Travailleurs de la Région Lyonnaise. Abdominal aortic calcification (AAC) was assessed semi-quantitatively on lateral dual energy X-ray absorptiometry (DXA) spine scans. Serum fetuin-A was measured by an immunoassay. After adjustment for confounders (age, lifestyle, body composition, health status, treatment, glomerular filtration rate [GFR], hormones, and cytokines), prevalence of severe AAC (AAC score4) decreased with increasing fetuin-A levels (OR=0.68 per SD increase, 95% CI: 0.54-0.84, p0.001). After adjustment for confounders, low fetuin-A and hypertension were each associated with higher odds of AAC4. Coexistence of low serum fetuin-A levels and heavy smoking, elevated fibroblast growth factor 23 levels or low serum dickkopf-1 levels were associated with higher odds of AAC4. Similar results were obtained for 789 men with GFR60 mL/min/1.73 m(2). Similar results were obtained when severe AAC was defined as AAC score3 or AAC5. Thus, lower serum fetuin-A levels are associated with severe AAC, suggesting that poor calcification inhibitory potential contributes to vascular calcification, independently of renal impairment. |
| Databáze: | OpenAIRE |
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