Human Dorsal Root Ganglion Stimulation Reduces Sympathetic Outflow and Long-Term Blood Pressure
| Autor: | Yrsa Bergmann Sverrisdóttir, George Hadjipavlou, Alexander L. Green, Alexander R. Kent, Sean Martin, David J. Paterson, James J. FitzGerald |
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| Rok vydání: | 2020 |
| Předmět: |
BP
blood pressure 0301 basic medicine medicine.medical_specialty hypertension sympathetic nerve activity Pain relief DBP diastolic blood pressure Sympathetic nerve Stimulation 030204 cardiovascular system & hematology MRBA% median relative burst amplitude 03 medical and health sciences 0302 clinical medicine Lumbar Dorsal root ganglion Clinical Research Internal medicine Neuromodulation medicine DRG stimulation SCS spinal cord stimulation BI burst incidence health care economics and organizations HR heart rate business.industry SBP systolic blood pressure blood pressure DRGS dorsal root ganglion stimulation MAP mean arterial pressure DRG dorsal root ganglion MME morphine milligram equivalent MSNA muscle sympathetic nerve activity 030104 developmental biology Blood pressure medicine.anatomical_structure VAS visual analogue score of pain neuromodulation Cardiology BF burst frequency Sympathetic outflow Cardiology and Cardiovascular Medicine business |
| Zdroj: | JACC: Basic to Translational Science |
| ISSN: | 2452-302X |
| DOI: | 10.1016/j.jacbts.2020.07.010 |
| Popis: | Visual Abstract Highlights • DRGS at upper lumbar levels significantly reduces sympathetic nerve firing • Reduction in sympathetic activity appears to be independent to pain relief • DRGS significantly reduced BP at 6 months and 2 years • BP reduction was lateralized to DRGS on the left side • Three refractory hypertensives became normotensive after chronic stimulation. Summary This study hypothesized that dorsal root ganglion (DRG) stimulation would reduce sympathetic nerve activity and would alter hemodynamic variables. This study directly recorded muscle sympathetic nerve activity during ON and OFF stimulation of the DRG while measuring hemodynamic parameters. DRG stimulation significantly reduced the firing frequency of sympathetic nerves, as well as significantly reducing blood pressure, with greater reductions evident when stimulation was left-sided. Left-sided DRG stimulation lowers sympathetic nerve activity, leading to long-term phenotypic changes. This raises the potential of DRG stimulation being used to treat de novo autonomic disorders such as hypertension or heart failure. |
| Databáze: | OpenAIRE |
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