Novel three-break rearrangement and cryptic translocations leading to colocalization of MYC and IGH signals in B-cell acute lymphoblastic leukemia
| Autor: | Joelle Tchinda, Thomas Büchner, Wolfgang E. Berdel, Sarah Volpert, Jürgen Horst |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Gene Rearrangement
Male Cancer Research Derivative chromosome Genes myc Chromosome Locus (genetics) Karyotype Chromosomal translocation Gene rearrangement Biology Immunoglobulin light chain Burkitt Lymphoma Translocation Genetic immune system diseases Karyotyping hemic and lymphatic diseases Genetics Cancer research Humans Immunoglobulin heavy chain Immunoglobulin Heavy Chains Molecular Biology In Situ Hybridization Fluorescence Aged |
| Zdroj: | Cancer Genetics and Cytogenetics. 165:180-184 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/j.cancergencyto.2005.08.015 |
| Popis: | Reciprocal translocations involving the MYC locus and immunoglobulin heavy chain (IGH) and light chain (IgK and IgL) loci are characteristic for non-Hodgkin lymphomas, especially Burkitt lymphoma, and have been described in B-cell acute lymphoblastic leukemia (B-ALL). We report on a case of B-ALL of L3 morphology with MYC-IGH translocation. Bone marrow metaphases were characterized using conventional cytogenetics and molecular cytogenetic techniques. G-banding showed a hyperdiploid complex rearranged male karyotype with 51 chromosomes. Additionally to other chromosome changes, a three-break rearrangement involving 6p21, 8q24, and 14q32, as well as cryptic translocations of IGH locus to MYC locus were detected. To our knowledge, this is the first case with colocalizations of MYC and IGH in a three-break rearrangement involving 6p21 and on an additional derivative chromosome as results of cryptic translocations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect