HIV nucleoside reverse transcriptase inhibitors

Autor:	Franck Amblard, Dharmeshkumar Patel, Eleftherios Michailidis, Steven J. Coats, Mahesh Kasthuri, Nicolas Biteau, Zahira Tber, Maryam Ehteshami, Raymond F. Schinazi
Rok vydání:	2022
Předmět:	Pharmacology Anti-HIV Agents Antiretroviral Therapy Highly Active Organic Chemistry Drug Discovery Drug Resistance Viral Humans Reverse Transcriptase Inhibitors HIV Infections Nucleosides General Medicine HIV Reverse Transcriptase
Zdroj:	European journal of medicinal chemistry. 240
ISSN:	1768-3254
Popis:	More than 40 years into the pandemic, HIV remains a global burden and as of now, there is no cure in sight. Fortunately, highly active antiretroviral therapy (HAART) has been developed to manage and suppress HIV infection. Combinations of two to three drugs targeting key viral proteins, including compounds inhibiting HIV reverse transcriptase (RT), have become the cornerstone of HIV treatment. This review discusses nucleoside reverse transcriptase inhibitors (NRTIs), including chain terminators, delayed chain terminators, nucleoside reverse transcriptase translocation inhibitors (NRTTIs), and nucleotide competing RT inhibitors (NcRTIs); focusing on their history, mechanism of action, resistance, and current clinical application, including long-acting regimens.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026d737eeaf4e5b12209159babf0fa3c https://pubmed.ncbi.nlm.nih.gov/35792384 Zobrazit plný text záznamu Full Text from ScienceDirect