Coronary flow in neonates with impaired intrauterine growth

Autor: Ann Thuring, Peter Malcus, Vineta Fellman, Erkki Pesonen, Elhadi H. Aburawi
Rok vydání: 2011
Předmět:
Cardiac function curve
medicine.medical_specialty
Heart Ventricles
Statistics as Topic
Diastole
Hemodynamics
Intrauterine growth restriction
Gestational Age
Fractional flow reserve
Anterior Descending Coronary Artery
Doppler echocardiography
Ultrasonography
Prenatal
Umbilical Arteries
Reference Values
medicine.artery
Internal medicine
medicine
Confidence Intervals
Humans
Radiology
Nuclear Medicine and imaging
Uterine artery
Subclinical infection
Coronary flow
Fetal Growth Retardation
medicine.diagnostic_test
business.industry
Myocardium
Infant
Newborn
Gestational age
Umbilical artery
Fetal weight
medicine.disease
Fractional Flow Reserve
Myocardial
Uterine Artery
Case-Control Studies
Pediatrics
Perinatology and Child Health
Cardiology
Cardiology and Cardiovascular Medicine
business
Blood Flow Velocity
Zdroj: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 25(3)
ISSN: 1097-6795
Popis: Subclinical myocardial injury has been reported in newborns with fetal weights2 SDs for gestational age. Intrauterine growth restriction might affect cardiac function and coronary flow (CF).Seventeen newborns with intrauterine growth restriction and 15 age-matched healthy controls were enrolled in the study. Blood flow in the umbilical artery and maternal uterine artery was assessed using Doppler velocimetry. Cardiac function and left anterior descending coronary artery CF were measured using transthoracic Doppler echocardiography at 1 week of age.The mean growth deviation of the newborns from normal was -2.5 ± 0.2 SDs. Percentage left ventricular shortening fraction was 39 ± 4.3% in patients and 42 ± 4.1% in controls (P = .40), and the mean left ventricular mass index was 86.6 g/m(2) in patients and 73.7 g/m(2) in controls (P.01). The mean left anterior descending coronary artery diameter was 0.99 ± 0.1 mm in patients and 0.8 ± 0.1 mm in controls (P = .002). The left anterior descending coronary artery flow velocity-time integral was correlated with left ventricular mass index (r = 0.31, P = .007) and with mitral peak E/A ratio (r = 0.74, P = .01). Intrauterine growth restriction was associated with increased peak flow velocity in diastole (34.5 ± 4 vs 19 ± 6 cm/sec in controls, P = .0001), as well as increased CF (37 ± 7.3 vs 8.2 ± 3.0 mL/min in controls, P = .001).CF is significantly increased in neonates with impaired intrauterine growth. Left ventricular mass index is increased, but systolic and diastolic function remains normal. The clinical significance of increased CF is unclear, but it might lead to decreased CF reserve.
Databáze: OpenAIRE
Externí odkaz: