Soliseptide A, A Cyclic Hexapeptide Possessing Piperazic Acid Groups from Streptomyces solisilvae HNM30702

Autor:	Dongyi Huang, Yonghong Liu, Weihao Chen, Ziwen Cong, Zhengchao Tu, Junfeng Wang, Xiaolong Huang, Chenxi Hou
Rok vydání:	2018
Předmět:	Piperazic acid biology 010405 organic chemistry Chemistry Stereochemistry Organic Chemistry biology.organism_classification 01 natural sciences Biochemistry Streptomyces 0104 chemical sciences 010404 medicinal & biomolecular chemistry Physical and Theoretical Chemistry Single crystal
Zdroj:	Organic letters. 20(5)
ISSN:	1523-7052
Popis:	Soliseptide A (1), a cyclic hexapeptide possessing piperazic acid groups, together with two known azalomycin derivatives (2 and 3) were isolated from Streptomyces solisilvae HNM30702. Their structures were determined through spectroscopic methods and single crystal X-ray diffraction analysis. Soliseptide A (1) possessed a cyclic hexapeptide core featured with two piperazic acid units rarely discovered in nature, and exhibited weak antibacterial and antiviral activities. Besides, compounds 2 and 3 displayed significant fungicidal effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026c16ecd284a63b8f6a2c98d2919623 https://pubmed.ncbi.nlm.nih.gov/29441782 Zobrazit plný text záznamu