Effects of indole-3-carbinol on steroid hormone profile and tumor progression in a mice model of canine inflammatory mammarycancer
| Autor: | Asunción Martín-Ruiz, Laura Peña, J. C. Illera, Sara Caceres, A. González-Gil, Lucía Teresa Díez-Córdova |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research Indoles medicine.medical_treatment Phytochemicals Estrogen receptor Apoptosis Mice SCID Inflammatory breast cancer lcsh:RC254-282 Metastasis 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Breast cancer Dogs Canine inflammatory mammary cancer (IMC) Genetics medicine Indole-3-carbinol Animals Anticarcinogenic Agents Gonadal Steroid Hormones Cell Proliferation Steroid hormones business.industry Inflammatory breast cancer (IBC) Xenograft Cancer Mammary Neoplasms Experimental medicine.disease Mice model lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xenograft Model Antitumor Assays Steroid hormone Disease Models Animal 030104 developmental biology Oncology chemistry Tumor progression 030220 oncology & carcinogenesis Cancer research Female Inflammatory Breast Neoplasms Indole-3-carbinol (I3C) business Research Article |
| Zdroj: | BMC Cancer, Vol 18, Iss 1, Pp 1-9 (2018) BMC Cancer |
| ISSN: | 1471-2407 |
| Popis: | Background Indole-3-carbinol, derived from Cruciferous vegetables is an estrogen receptor antagonist considered a preventive agent that is naturally present in diet. There are no previous studies on its effects in human inflammatory breast cancer or canine inflammatory mammary cancer that is the most aggressive type of breast cancer. Methods The aim of this study was to analyze the effect of indole-3-carbinol on a SCID mice xenograft model of canine inflammatory mammary cancer, using equivalent human oral dose as a preventive therapy in humans for 3 weeks. Results Indole-3-carbinol treatment decreased tumor proliferation and increased apoptosis, although tumor embolization and liver metastasis were observed in some animals. There was a characteristic subpopulation of lipid-rich cells and increased contents of select steroid hormones in tumor homogenates and serum. Conclusions Our data reveal for the first time that the ingestion of indole-3-carbinol, as administered, diminishes proliferation and increases apoptosis of tumor cells in an experimental model of inflammatory breast cancer, although this effect could not be enough to avoid the appearance of tumor embolization and metastasis. Future clinical trials will be needed to clarify the usefulness of indole-3-carbinol in this cancer and to understand the molecular mechanisms involved. |
| Databáze: | OpenAIRE |
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