Janus nanocarrier powered by bi-enzymatic cascade system for smart delivery
| Autor: | Ramón Martínez-Máñez, Natalia Joga, Daniel Torres, Beatriz de Luis, Sandra Jimenez-Falcao, Paloma Martínez-Ruiz, Félix Sancenón, Reynaldo Villalonga, Antoni Llopis Lorente, Alba García-Fernández |
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| Rok vydání: | 2019 |
| Předmět: |
Biomedical Engineering
Nanotechnology Multifunctional Nanoparticles 02 engineering and technology 010402 general chemistry Gluconates 01 natural sciences Glucose Oxidase Hydrolysis chemistry.chemical_compound Drug Delivery Systems Humans General Materials Science Glucose oxidase Janus Nanodevice Drug Carriers beta-Fructofuranosidase biology Chemistry General Chemistry General Medicine Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology 0104 chemical sciences Invertase Doxorubicin biology.protein Gluconic acid Nanocarriers 0210 nano-technology Mesoporous material HeLa Cells |
| Zdroj: | Journal of Materials Chemistry B r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) Centro de Investigación Principe Felipe (CIPF) r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) instname |
| ISSN: | 2050-7518 2050-750X |
| Popis: | We report herein the assembly of an integrated nanodevice with bi-enzymatic cascade control for on-command cargo release. This nanocarrier is based on Au-mesoporous silica Janus nanoparticles capped at the mesoporous face with benzimidazole/beta-cyclodextrin-glucose oxidase pH-sensitive gate-like ensembles and functionalized with invertase on the gold face. The rationale for this delivery mechanism is based on the invertase-mediated hydrolysis of sucrose yielding glucose, which is further transformed into gluconic acid by glucose oxidase causing the disruption of the pH-sensitive supramolecular gates at the Janus nanoparticles. This enzyme-powered device was successfully employed in the autonomous and on-demand delivery of doxorubicin in HeLa cancer cells. |
| Databáze: | OpenAIRE |
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