Exploring mitochondrial cholesterol signalling for therapeutic intervention in neurological conditions
| Autor: | Radha Desai, Michelangelo Campanella |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Settore BIO/06 Mitochondrion Bioinformatics Themed Section: Review Articles DNA Mitochondrial 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Intervention (counseling) Medicine Animals Humans Pharmacology Cholesterol business.industry Lipid metabolism DNA Mitochondria Mitochondrial 030104 developmental biology Signalling chemistry Nervous System Diseases business 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Br J Pharmacol |
| Popis: | The pharmacological targeting of cholesterol levels continues to generate interest due to the undoubted success of therapeutic agents, such as statins, in extending life expectancy by modifying the prognosis of diseases associated with the impairment of lipid metabolism. Advances in our understanding of mitochondrial dysfunction in chronic age-related diseases of the brain have disclosed an emerging role for mitochondrial cholesterol in their pathophysiology, thus delineating an opportunity to provide mechanistic insights and explore strategies of intervention. This review draws attention to novel signalling mechanisms in conditions linked with impaired metabolism associated with impaired handling of cholesterol and its oxidized forms (oxysterols) by mitochondria. By emphasizing the role of mitochondrial cholesterol in neurological diseases, we here call for novel approaches and new means of assessment. LINKED ARTICLES: This article is part of a themed section on Mitochondrial Pharmacology: Featured Mechanisms and Approaches for Therapy Translation. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.22/issuetoc. |
| Databáze: | OpenAIRE |
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