The role of 2-octyl cyanoacrylate in prevention of penile adhesions after circumcision: A prospective, randomized trial
| Autor: | Hanna Alemayehu, Shawn D. St. Peter, Charles L. Snyder, Katherine W. Gonzalez, Ashwini S. Poola, Nicole E. Sharp |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty 030232 urology & nephrology Adhesion (medicine) Tissue Adhesions law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial law 030225 pediatrics Humans Medicine Cyanoacrylates Prospective Studies Sutures business.industry Infant Newborn Infant General Medicine medicine.disease Anti-Bacterial Agents Surgery 2-Octyl cyanoacrylate Treatment Outcome Circumcision Male chemistry Cyanoacrylate Treatment study Pediatrics Perinatology and Child Health Tissue Adhesives Level ii business Complication Parent satisfaction |
| Zdroj: | Journal of Pediatric Surgery. 52:1886-1890 |
| ISSN: | 0022-3468 |
| DOI: | 10.1016/j.jpedsurg.2017.08.052 |
| Popis: | Penile adhesions are the most common complication after circumcision, although strategies to decrease them are poorly studied. We conducted a prospective, randomized trial comparing the use of 2-octyl cyanoacrylate (glue) skin adhesive to hydrophobic ointment after circumcision.Patients7years old undergoing circumcision were randomized to glue around the sutures and corona of the penis or antibiotic ointment. The primary outcome variable was postoperative penile adhesions. Utilizing a power of 0.8 and an alpha of 0.05, 168 patients were calculated for each arm. Because of high attrition, we planned to include up to 500 patients. Presence/absence of adhesions was evaluated 2-4weeks postop. Parents subjectively scored happiness, comfort, distress, and concern on a Likert scale 1-5.From 11/2012 through 7/2016, 409 patients were enrolled. Adhesion data were available on 243 patients. There was no difference between glue (16.8%) and those with antibiotic ointment (15.2%) (p=0.88) or in parental satisfaction across all areas measured. 165 patients were lost to follow-up, evenly distributed between the two groups (38% vs. 42%, p=0.49).The placement of 2-octyl cyanoacrylate skin adhesive does not decrease the rate of postoperative penile adhesions after circumcision. Parent satisfaction outcomes are similar.Treatment study.Level II. |
| Databáze: | OpenAIRE |
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