Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes
| Autor: | Chelsea D. Landon, Christina L. Hofmann, Paul R. Stauffer, Mark W. Dewhirst |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Oncology
medicine.medical_specialty Carcinoma Hepatocellular medicine.medical_treatment Thermal ablation Thermosensitive liposomes Catheter ablation Metastatic liver cancer Article Metastasis Internal medicine medicine Humans business.industry Liver Neoplasms Cancer Hyperthermia Induced medicine.disease Prognosis Intercurrent disease Hepatocellular carcinoma Liposomes Catheter Ablation Surgery business |
| Zdroj: | Surgical oncology clinics of North America. 22(3) |
| ISSN: | 1558-5042 |
| Popis: | There is a need for therapies that can effectively treat primary hepatocellular carcinoma (HCC) as well as metastases to the liver. HCC is the fifth most common cancer worldwide and the fourth most common cause for cancer death.1 Metastasis to the liver occurs commonly from primary cancers of the gastrointestinal track and other solid tumors. Surgical resection is an option for less than 30% of patients presenting with metastases.1,2 These patients are often not good surgical candidates, because of the location of the tumor or because of intercurrent disease, such as cirrhosis.2 However, thermal ablation is a cost-effective, nonsurgical option for treatment of patients with HCC and liver metastases3 and is currently practiced worldwide. In this review, a new approach is discussed, combining thermal ablation with drug-carrying thermosensitive liposomes. The rationale for this approach is presented and discussed in light of current liposome formulations and methods to achieve thermal ablation. A summary of preclinical and clinical studies that are relevant to treatment of primary and metastatic liver cancer is also presented. |
| Databáze: | OpenAIRE |
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