Role of 18F-FDG PET/CT in restaging and follow-up of patients with GIST
| Autor: | Raffaele Giubbini, Bonacina Mattia, Domenico Albano, Francesco Bertagna |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Poor prognosis PET/CT Restaging Gastrointestinal Stromal Tumors Urology Sensitivity and Specificity 030218 nuclear medicine & medical imaging 18F-FDG PET/CT GIST 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Internal medicine Positron Emission Tomography Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging Stromal tumor neoplasms Aged Neoplasm Staging Aged 80 and over PET-CT Radiological and Ultrasound Technology GiST business.industry Gastroenterology Hepatology Middle Aged Prognosis True negative 030220 oncology & carcinogenesis Histopathology Fdg pet ct Female Radiology Neoplasm Recurrence Local Radiopharmaceuticals business Follow-Up Studies |
| Zdroj: | Abdominal radiology (New York). 45(3) |
| ISSN: | 2366-0058 |
| Popis: | Gastrointestinal stromal tumor (GIST) is a rare tumor with high risk of recurrence and poor prognosis in case of advanced GIST. The aim of this study was to evaluate the possible role of 18F-FDG PET/CT in restaging GIST. Fifty-four patients (30 male) with histological proven GIST underwent 100 18F-FDG PET/CT for restaging in suspected recurrence or during follow-up. Histopathology results and/or clinical/imaging follow-up for at least 12 months were considered as reference standard. Moreover, the diagnostic accuracy and clinical impact of 18F-FDG PET/CT were calculated. Twenty-seven (27%) 18F-FDG PET/CT were positive, while the remaining 73 (73%) were negative. Sensitivity, specificity, PPV, NPV, and accuracy of PET/CT were 89% (95% CI 72–98%), 97% (95% CI 90–100%), 93% (95% CI 76–98%), 96% (95% CI 89–98%), and 95% (95% CI 89–98%). 18F-FDG PET/CT had a positive clinical impact in 18/100 studies changing the management, in 8 cases switching from local therapy to systemic therapy due to the detection of disseminate disease at PET/CT, in three cases recognizing relapse not detected by conventional imaging, and in 7 cases demonstrating to be true negative and avoiding unnecessary therapies. 18F-FDG PET/CT seems to be an accurate method for detection and localization of local and distant recurrence in GIST with good sensitivity and specificity and significant impact on clinical decision-making. |
| Databáze: | OpenAIRE |
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