Osteoprotegerin CGA haplotype protection against cerebrovascular complications in anti-CCP negative patients with rheumatoid arthritis

Autor: Francisco Javier López-Longo, Javier Martín, José A. Miranda-Filloy, Ricardo Blanco, Alfonso Corrales, Trinitario Pina, Mercedes García-Bermúdez, Miguel A. González-Gay, Begoña Ubilla, Fernanda Genre, Javier Llorca, Carmen Gómez-Vaquero, Santos Castañeda, Alejandro Balsa, Raquel López-Mejías, Isidoro González-Álvaro, Carlos González-Juanatey, Benjamín Fernández-Gutiérrez, Patricia Carreira, Dora Pascual-Salcedo, Luis Rodriguez-Rodriguez
Přispěvatelé: Universidad de Cantabria, Universitat de Barcelona
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Arthritis
lcsh:Medicine
Disease
Gastroenterology
Arthritis
Rheumatoid
Medicine and Health Sciences
Medicine
Cerebrovascular disease
lcsh:Science
education.field_of_study
Multidisciplinary
Nucleotides
Middle Aged
Cardiovascular Diseases
Rheumatoid arthritis
Female
Research Article
Malalties cerebrovasculars
Adult
musculoskeletal diseases
medicine.medical_specialty
Immunology
Population
Cardiology
Rheumatoid Arthritis
Artritis reumatoide
Peptides
Cyclic
Polymorphism
Single Nucleotide
Autoimmune Diseases
Rheumatology
Osteoprotegerin
Internal medicine
Diabetes mellitus
Genetics
Humans
education
Aged
Autoantibodies
Evolutionary Biology
business.industry
lcsh:R
Autoantibody
Biology and Life Sciences
Cardiovascular Disease Risk
medicine.disease
Nucleòtids
Cerebrovascular Disorders
Haplotypes
Spain
Genetic Polymorphism
Clinical Immunology
lcsh:Q
business
Population Genetics
Dyslipidemia
Zdroj: PLoS ONE, Vol 9, Iss 9, p e106823 (2014)
PLoS One. 2014 Sep 3;9(9):e106823
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Recercat. Dipósit de la Recerca de Catalunya
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE
ISSN: 1932-6203
Popis: © 2014 Genre et al. Introduction: Rheumatoid arthritis is an inflammatory disease with high incidence of cardiovascular disease due to accelerated atherosclerosis. Osteoprotegerin (OPG) has been associated with increased risk of atherosclerotic disease in the general population. Several polymorphisms in the OPG gene with functional effects on cardiovascular disease in nonrheumatic individuals have been described. Therefore, we aimed to analyze the effect of three of these functional OPG polymorphisms on the risk of cardiovascular disease in a large and well-characterized cohort of Spanish patients with rheumatoid arthritis.
Databáze: OpenAIRE
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