Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans
| Autor: | M. Juliana McElrath, Jack Heptinstall, Xiaoying Shen, Cecilia Morgan, Shuying S. Li, Harriet L. Robinson, Giuseppe Pantaleo, Shelly Karuna, Nicole L. Yates, Shannon Grant, Nicole Grunenberg, Glenda Gray, Peter B. Gilbert, Ashley Clayton, Laura Polakowski, April K. Randhawa, Sheetal Sawant, Mary Allen, Xue Han, Ying Huang, Janine Maenza, Kelly E. Seaton, Paul Spearman, Ann Duerr, Yunda Huang, Aaron Deal, Gavin J. Churchyard, Georgia D. Tomaras, Paul A. Goepfert |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Protein vaccines Saliva Immunogen Immunology Gp41 Article DNA vaccines 03 medical and health sciences 0302 clinical medicine Medicine Pharmacology (medical) Vector (molecular biology) RC254-282 Pharmacology Vaccines biology business.industry virus diseases Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC581-607 Vaccination 030104 developmental biology Infectious Diseases Immunization 030220 oncology & carcinogenesis Meta-analysis biology.protein Immunologic diseases. Allergy Antibody business |
| Zdroj: | npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021) NPJ Vaccines |
| ISSN: | 2059-0105 |
| DOI: | 10.1038/s41541-021-00305-8 |
| Popis: | We studied mucosal immune responses in six HIV-1 vaccine trials investigating different envelope (Env)-containing immunogens. Regimens were classified into four categories: DNA/vector, DNA/vector plus protein, protein alone, and vector alone. We measured HIV-1-specific IgG and IgA in secretions from cervical (n = 111) and rectal swabs (n = 154), saliva (n = 141), and seminal plasma (n = 124) and compared to corresponding blood levels. Protein-containing regimens had up to 100% response rates and the highest Env-specific IgG response rates. DNA/vector groups elicited mucosal Env-specific IgG response rates of up to 67% that varied across specimen types. Little to no mucosal IgA responses were observed. Overall, gp41- and gp140-specific antibodies dominated gp120 mucosal responses. In one trial, prior vaccination with a protein-containing immunogen maintained durability of cervical and rectal IgG for up to 17 years. Mucosal IgG responses were boosted after revaccination. These findings highlight a role for protein immunization in eliciting HIV-1-specific mucosal antibodies and the ability of HIV-1 vaccines to elicit durable HIV-1-specific mucosal IgG. |
| Databáze: | OpenAIRE |
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