p-Glycoprotein expression in malignant melanoma
| Autor: | Blandine Fuchs, Ludwig Suter, Ostmeier H |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Cancer Research
medicine.medical_specialty Skin Neoplasms medicine.medical_treatment Drug Resistance Internal medicine Gene expression medicine Humans ATP Binding Cassette Transporter Subfamily B Member 1 Melanoma P-glycoprotein chemistry.chemical_classification Chemotherapy Membrane Glycoproteins Hematology biology General Medicine medicine.disease Neoplasm Proteins Multiple drug resistance Oncology chemistry Lymphatic Metastasis Immunology Cancer research biology.protein Efflux Glycoprotein |
| Zdroj: | Journal of Cancer Research and Clinical Oncology. 117:168-171 |
| ISSN: | 1432-1335 0171-5216 |
| DOI: | 10.1007/bf01613142 |
| Popis: | In some human malignancies resistance to chemotherapy is caused by an energy-dependent efflux system, responsible for the removal of chemotherapeutics out of the resistant tumor cells. A major component of this efflux system is the permeability glycoprotein (p-glycoprotein), which depends on the multidrug-resistance gene MDR1. We have tested p-glycoprotein in primary and metastatic human melanoma by use of the monoclonal antibody C219; a substantial expression was only observed in 1/37 primary melanomas and in 1/27 melanoma metastases. None of the patients with negative metastases responded to chemotherapy. Moreover a complete remission of metastatic growth was observed in the patient with the metastasis significantly expressing the p-glycoprotein. Sequential studies revealed no significant increase of p-glycoprotein-positive cells during and after chemotherapy. We conclude that drug resistance in human melanoma does not usually depend on the p-glycoprotein-related efflux system. Other mechanisms are obviously responsible for drug resistance in this human malignancy. |
| Databáze: | OpenAIRE |
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