Clinical significance of mucinous component in colorectal adenocarcinoma: a propensity score-matched study
| Autor: | Fei Yang, Hui Yang, Chuanwang Yan, Qing Sun, Wenguang Yuan, Li-jian Xia, Lili Chen, Wei Shang, Ran Liu |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Time Factors Colorectal cancer Adenocarcinoma Gastroenterology Survival prognosis Surgical oncology Risk Factors Internal medicine Genetics medicine Confidence Intervals Humans Colorectal adenocarcinoma Clinical significance Risk factor Propensity Score RC254-282 Aged Retrospective Studies Mucinous component Univariate analysis business.industry Research Smoking Mucins Neoplasms. Tumors. Oncology. Including cancer and carcinogens Middle Aged medicine.disease Prognosis Adenocarcinoma Mucinous Oncology ROC Curve Propensity score matching Multivariate Analysis Female business Colorectal Neoplasms |
| Zdroj: | BMC Cancer BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021) |
| ISSN: | 1471-2407 |
| Popis: | Background This study aims to investigate the clinical significance and prognostic value of mucinous component (MC) in colorectal adenocarcinoma (AC). Methods Patients with colorectal AC and AC with MC (ACMC) (1–100%) underwent surgical resection between January 2007 and February 2018 were retrospectively reviewed. Propensity score matching (PSM) was performed according to a 1:1 ratio. Receiver-operating characteristic (ROC) curve was used to identify the optimal cut-off value of MC ratio for prognostic prediction. The clinicopathological features and 3-year overall survival (OS) of AC patients, mucinous adenocarcinoma (MAC) (MC > 50%) patients, and ACMC (1–50%) patients were compared before and after matching. Multivariable analysis was used for analyzing independent risk factors related to prognosis. Results A total of 532 patients were enrolled in this study. Patients with AC, MAC, and ACMC (1–50%) exhibited different clinicopathological features. However, their 3-year OS rates were similar (82.00% vs. 74.11% vs. 81.48%, P = 0.38). After matching, ROC curve determined 70% as the optimal cut-off value. And patients with ACMC > 70% had a much poorer 3-year OS compared with ACMC (1–70%) patients and AC patients (47.37% vs. 86.15% vs. 79.76%, P 70% was revealed as a risk factor for poor survival in univariate analysis (HR = 1.643, 95%CI = 1.025–2.635, P = 0.039), though not an independent risk factor in multivariable analysis (HR = 1.550, 95%CI = 0.958–2.507, P = 0.074). Conclusions MAC is usually diagnosed at an advanced stage. MAC has a similar survival with AC and ACMC (1–50%) patients before and after matching. Patients with ACMC > 70% exhibited a much poorer OS, and should be given more clinical attention. |
| Databáze: | OpenAIRE |
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