Anterograde Axonal Transport in Neuronal Homeostasis and Disease
| Autor: | Marco Terenzio, Laurent Guillaud, Sara Emad El-Agamy, Miki Otsuki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
intracellular transport Dynein Synaptogenesis Review Biology kinesin lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine local translation axon growth Molecular motor medicine Axon liquid phase separation lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Molecular Biology synaptogenesis Neurodegeneration neurodegeneration medicine.disease Anterograde axonal transport 030104 developmental biology medicine.anatomical_structure nervous system Axoplasmic transport Kinesin Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Molecular Neuroscience Frontiers in Molecular Neuroscience, Vol 13 (2020) |
| ISSN: | 1662-5099 |
| Popis: | Neurons are highly polarized cells with an elongated axon that extends far away from the cell body. To maintain their homeostasis, neurons rely extensively on axonal transport of membranous organelles and other molecular complexes. Axonal transport allows for spatio-temporal activation and modulation of numerous molecular cascades, thus playing a central role in the establishment of neuronal polarity, axonal growth and stabilization, and synapses formation. Anterograde and retrograde axonal transport are supported by various molecular motors, such as kinesins and dynein, and a complex microtubule network. In this review article, we will primarily discuss the molecular mechanisms underlying anterograde axonal transport and its role in neuronal development and maturation, including the establishment of functional synaptic connections. We will then provide an overview of the molecular and cellular perturbations that affect axonal transport and are often associated with axonal degeneration. Lastly, we will relate our current understanding of the role of axonal trafficking concerning anterograde trafficking of mRNA and its involvement in the maintenance of the axonal compartment and disease. |
| Databáze: | OpenAIRE |
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