Role of APP for dendritic spine formation and stability
| Autor: | Christian K.E. Jung, Jochen Herms |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Dendritic spine
Dendritic Spines physiology [Amyloid beta-Protein Precursor] Synapse Mice Amyloid beta-Protein Precursor Postsynaptic potential mental disorders Amyloid precursor protein Animals Humans ddc:610 Cognitive decline Physiological function biology Protein Stability General Neuroscience Compartment (ship) physiology [Dendritic Spines] Synapses ultrastructure [Synapses] Excitatory postsynaptic potential biology.protein ultrastructure [Dendritic Spines] physiology [Synapses] Psychology Neuroscience |
| Zdroj: | Experimental brain research 217(3-4), 463-470 (2011). doi:10.1007/s00221-011-2939-x |
| DOI: | 10.1007/s00221-011-2939-x |
| Popis: | The amyloid precursor protein (APP) is transported in high amounts to the presynaptic endings where its function is still unknown. Several studies indicate that lack of APP or its overexpression affects the number of dendritic spines, the postsynaptic compartment of excitatory synapses. Since synapse loss has been identified as one of the most important structural correlates of cognitive decline in Alzheimer's diseases (AD), the physiological function of APP at synapses, specifically at dendritic spines, has come into focus in AD research. This review intends to give an overview of the very controversial results on APP expression on dendritic spine number in the mouse brain. |
| Databáze: | OpenAIRE |
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