A receptor for interleukin 10 is related to interferon receptors
| Autor: | J Bazan, Ying Liu, Tariq A. Khan, A S Ho, K W Moore, Di-Hwei Hsu |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
DNA
Complementary Cell division medicine.medical_treatment Molecular Sequence Data Gene Expression Biology Transfection law.invention Mice law Interferon medicine Animals Receptors Interleukin-10 Amino Acid Sequence RNA Messenger Cloning Molecular Receptor DNA Primers Receptors Interferon Multidisciplinary Sequence Homology Amino Acid Receptors Interleukin Molecular biology Interleukin 10 Cytokine Recombinant DNA Signal transduction Sequence Alignment Cell Division Research Article Signal Transduction medicine.drug |
| Zdroj: | Proceedings of the National Academy of Sciences. 90:11267-11271 |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | We isolated cDNAs encoding a mouse interleukin 10 receptor (mIL-10R) from mouse mast cell and macrophage cell lines. The two cDNAs are substantially identical and express an approximately 110-kDa polypeptide in COS7 cells, which binds mIL-10 specifically. A mouse pro-B-cell line (Ba/F3) expressing transfected recombinant mIL-10R binds IL-10 with high affinity (approximately 70 pM) and proliferates in response to mIL-10. mIL-10R is structurally related to interferon receptors (IFNRs). Since IL-10 inhibits macrophage activation by IFN-gamma, a possible implication of this relationship interaction of IL-10R and IFN-gamma R or their signaling pathways. |
| Databáze: | OpenAIRE |
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