Different Growth Factor Activation in the Right and Left Ventricles in Experimental Volume Overload
| Autor: | Maria Boddi, Avio Maria Perna, Gian Franco Gensini, Ilaria Cecioni, Simone Vanni, Pietro Amedeo Modesti, Camilla Lumachi, Iacopo Bertolozzi |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Swine Cardiac Volume Heart Ventricles medicine.medical_treatment Volume overload Angiotensin II receptor antagonist Biology Muscle hypertrophy Insulin-like growth factor Internal medicine Internal Medicine medicine Animals RNA Messenger Insulin-Like Growth Factor I Growth Substances Endothelin-1 Hypertrophy Right Ventricular Angiotensin II Growth factor Hemodynamics Adaptation Physiological medicine.anatomical_structure Endocrinology experimental overload cardiac valve disease aortic valve Ventricle ACE inhibitor Female Hypertrophy Left Ventricular Collagen medicine.drug |
| Zdroj: | Hypertension. 43:101-108 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.0000104720.76179.18 |
| Popis: | Mechanical factors play a key role in activation of cardiac growth factor response in hemodynamic overload, and both cooperate in myocardial remodeling. The present study was performed to investigate whether a different growth factor response is activated in the right and left ventricles in aortocaval fistula and its effects on regional myocardial adaptation. Relations between regional growth factor expression (angiotensin II, insulin-like growth factor-I, and endothelin-1), myocyte shape changes, and collagen deposition were investigated at mRNA and peptide levels in adult pigs after the creation of an aortocaval fistula distal to the renal arteries (n=15) and in sham-operated animals (n=15). The role of angiotensin II was investigated by the administration of angiotensin-converting enzyme inhibitor or angiotensin II receptor antagonist. In the left ventricle, pure volume overload was accompanied by persistent increase of insulin-like growth factor-I mRNA expression, peptide concentration (2.2-fold versus sham at 3 months, P P |
| Databáze: | OpenAIRE |
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