Disappearance of Gastric Hyperplastic Polyps after the Discontinuation of Proton Pump Inhibitor in a Patient with Liver Cirrhosis
| Autor: | Jun Nakamura, Yasumasa Monobe, Kengo Yasugi, Tomohiro Tanikawa, Noriyo Urata, Ken Haruma, Mitsuhiko Suehiro, Hirofumi Kawamoto, Takuya Fujita, Takahito Oka, Miwa Kawanaka |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Cirrhosis medicine.drug_class Single Case Proton-pump inhibitor Endoscopic mucosal resection Proton pump inhibitor Gastroenterology Hypergastrinemia 03 medical and health sciences 0302 clinical medicine Internal medicine otorhinolaryngologic diseases Medicine Gastric Hyperplastic Polyp lcsh:RC799-869 Gastric hyperplastic polyp business.industry Stomach medicine.disease digestive system diseases Foveolar cell medicine.anatomical_structure surgical procedures operative Hyperplastic Polyp Gastric Polyp 030220 oncology & carcinogenesis lcsh:Diseases of the digestive system. Gastroenterology 030211 gastroenterology & hepatology business |
| Zdroj: | Case Reports in Gastroenterology Case Reports in Gastroenterology, Vol 15, Iss 1, Pp 202-209 (2021) |
| ISSN: | 1662-0631 |
| Popis: | Here, we report on a rare case of gastric hyperplastic polyps which disappeared after the discontinuation of proton pump inhibitor (PPI). The patient was an 83-year-old woman with liver cirrhosis and portal hypertension, along with gastroesophageal reflux disease treated by PPI. An initial upper gastrointestinal endoscopy showed unique polypoid lesions in the greater curvature of the stomach. Biopsy specimens of the lesions were diagnosed as hyperplastic polyps and she was followed. One year later, a second endoscopy showed that the lesions had increased in number and size, and an endoscopic mucosal resection (EMR) was performed for the main polyps. The resected specimens indicated a proliferation of foveolar epithelium cells with an increase of capillary ectasia and parietal cell hyperplasia, which was thought to be induced by hypergastrinemia from the PPI. Three months after the EMR, she was admitted because of bleeding from the remaining polyps along with an increase in new polyps. After conservative treatment, PPI was stopped and rebamipide was used. One year and 6 months later, an endoscopy showed the complete disappearance of all gastric polyps. |
| Databáze: | OpenAIRE |
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